Table 2 Areas of uncertainty and key questions in HFNC research
| • RCT in specific etiologies of ARF |
| • Describing early predictors of HFNC success in patients with ARF |
| • Optimal flow rate titration |
| • Should hypoxemic ARF patients with bilateral infiltrates who are treated with a HFNC be considered as ARDS patients? |
| • Cost-effectiveness analysis |
| • RCT in chronic respiratory diseases |