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Table 2 Areas of uncertainty and key questions in HFNC research

From: Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure

• RCT in specific etiologies of ARF
• Describing early predictors of HFNC success in patients with ARF
• Optimal flow rate titration
• Should hypoxemic ARF patients with bilateral infiltrates who are treated with a HFNC be considered as ARDS patients?
• Cost-effectiveness analysis
• RCT in chronic respiratory diseases