|
Demographics
| | |
|
Age (years)
|
71 (13)
|
66 (15)
|
|
Sex (female)
|
9 (36)
|
8 (32)
|
|
Race (white)
|
21 (84)
|
18 (78)
|
|
Co-morbidities
| | |
|
Coronary artery disease
|
11 (44)
|
9 (36)
|
|
Congestive heart failure
|
6 (24)
|
8 (32)
|
|
Hyperlipidemia
|
7 (28)
|
9 (36)
|
|
Hypertension
|
11 (44)
|
19 (76)
|
|
Chronic obstructive pulmonary disease
|
2 (8)
|
1 (4)
|
|
Diabetes
|
5 (20)
|
6 (24)
|
|
Liver disease
|
0 (0)
|
0 (0)
|
|
Renal disease
|
6 (24)
|
2 (8)
|
|
Cancer
|
2 (8)
|
1 (4)
|
|
Location of the arrest
| | |
|
In-hospital
|
6 (24)
|
6 (24)
|
|
Out-of-hospital
|
19 (76)
|
19 (76)
|
|
Arrest characteristics
| | |
|
Initial rhythm (shockable)
|
9 (36)
|
10 (40)
|
|
Downtime (minutes)
|
21 (10, 30)
|
16 (10, 38)
|
|
Presumed cause of the arrest
| | |
|
Primary cardiac
|
13 (52)
|
12 (48)
|
|
Pulmonary embolism
|
1 (4)
|
1 (4)
|
|
Respiratory
|
5 (20)
|
6 (24)
|
|
Metabolic/electrolyte
|
2 (8)
|
1 (4)
|
|
Sepsis
|
1 (4)
|
0 (0)
|
|
Other/unknown
|
3 (12)
|
5 (20)
|
|
Vital signs at enrollment
| | |
|
Heart rate
|
84 (18)
|
82 (21)
|
|
Systolic blood pressure
|
103 (97, 132)
|
109 (93, 130)
|
|
Diastolic blood pressure
|
61 (51, 70)
|
59 (48, 67)
|
|
Respiratory rate
|
22 (5)
|
23 (5)
|
|
Glasgow coma scale
|
3 (3, 6)
|
3 (3, 4)
|
|
Laboratory values at enrollment
| | |
|
Lactate (mmol/L)
|
2.8 (1.9, 5.3)
|
3.9 (1.9, 6.5)
|
|
Glucose (mg/dL)
|
237 (108)
|
226 (99)
|
|
pH
|
7.25 (0.14)
|
7.24 (0.13)
|
|
Time from ROSC to study drug (hours)
|
9.9 (7.3, 19.6)
|
12.7 (7.8, 15.6)
|
|
Time from start of vasopressor(s) to study drug (hours)
|
9.7 (6.3, 18.0)
|
11.4 (7.5, 15.0)
|
|
APACHE II score at enrollment
|
29 (5)
|
30 (7)
|
|
Induced hypothermia
|
19 (76)
|
16 (64)
|
