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Table 1 Selected baseline characteristics of the study patientsa

From: Corticosteroid therapy in refractory shock following cardiac arrest: a randomized, double-blind, placebo-controlled, trial

Characteristic Hydrocortisone (n = 25) Placebo (n = 25)
Demographics   
 Age (years) 71 (13) 66 (15)
 Sex (female) 9 (36) 8 (32)
 Race (white) 21 (84) 18 (78)
Co-morbidities   
 Coronary artery disease 11 (44) 9 (36)
 Congestive heart failure 6 (24) 8 (32)
 Hyperlipidemia 7 (28) 9 (36)
 Hypertension 11 (44) 19 (76)
 Chronic obstructive pulmonary disease 2 (8) 1 (4)
 Diabetes 5 (20) 6 (24)
 Liver disease 0 (0) 0 (0)
 Renal disease 6 (24) 2 (8)
 Cancer 2 (8) 1 (4)
Location of the arrest   
 In-hospital 6 (24) 6 (24)
 Out-of-hospital 19 (76) 19 (76)
Arrest characteristics   
 Initial rhythm (shockable) 9 (36) 10 (40)
 Downtime (minutes) 21 (10, 30) 16 (10, 38)
Presumed cause of the arrest   
 Primary cardiac 13 (52) 12 (48)
 Pulmonary embolism 1 (4) 1 (4)
 Respiratory 5 (20) 6 (24)
 Metabolic/electrolyte 2 (8) 1 (4)
 Sepsis 1 (4) 0 (0)
 Other/unknown 3 (12) 5 (20)
Vital signs at enrollment   
 Heart rate 84 (18) 82 (21)
 Systolic blood pressure 103 (97, 132) 109 (93, 130)
 Diastolic blood pressure 61 (51, 70) 59 (48, 67)
 Respiratory rate 22 (5) 23 (5)
 Glasgow coma scale 3 (3, 6) 3 (3, 4)
Laboratory values at enrollment   
 Lactate (mmol/L) 2.8 (1.9, 5.3) 3.9 (1.9, 6.5)
 Glucose (mg/dL) 237 (108) 226 (99)
 pH 7.25 (0.14) 7.24 (0.13)
Time from ROSC to study drug (hours) 9.9 (7.3, 19.6) 12.7 (7.8, 15.6)
Time from start of vasopressor(s) to study drug (hours) 9.7 (6.3, 18.0) 11.4 (7.5, 15.0)
APACHE II score at enrollment 29 (5) 30 (7)
Induced hypothermia 19 (76) 16 (64)
  1. ROSC return of spontaneous circulation, APACHE Acute Physiology and Chronic Health Evaluation
  2. aCategorical variables are presented as count (frequency) and continues variables as mean (standard deviation) or median (quartiles) depending on the normality of the data. Data missing on one patient for downtime, one patient for Glasgow coma score, one patient for pH, one patient for lactate, two patients for glucose and one patient on time from start of vasopressors to study drug