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Table 3 Analysis of outcome groupa

From: Piperacillin concentration in relation to therapeutic range in critically ill patients – a prospective observational study

Correlation of piperacillin trough levelsb with CRP levels

Number of patients

Correlation coefficient

p value

Trough level day 1 versus CRP day 1

13

0.13

0.67

Trough levels day 1 + 2 versus CRP day 2

13

- 0.22

0.94

Trough levels day 1 + 2 + 3 versus CRP day 3

12

- 0.31

0.33

Trough levels day 1 + 2 + 3 + 4 versus CRP day 4

11

- 0.66

0.028*

Trough levels day 1 + 2 versus the quotient CRP day 2/1

13

- 0.12

0.71

Trough levels day 1 + 2 + 3 versus the quotient CRP day 3/1

12

- 0.50

0.095

Trough levels day 1 + 2 + 3 + 4 versus the quotient CRP day 4/1

11

- 0.55

0.083

Pathogens of the outcome group

Number of pathogens

  

Burkholderia multivorans

1

  

Citrobacter freundii

1

  

Enterococcus faecalis

3

  

Klebsiella oxytoca

1

  

Klebsiella pneumoniae

1

  

Proteus mirabilis

1

  

Propionibacterium acnes

3

  

Pseudomonas aeruginosa

2

  

Pseudomonas oleovorans

1

  

Raoultella ornithinolytica

1

  

Staphylococcus aureus

4

  

Streptococci beta hemolytic group C

1

  

Streptococcus anginosus

1

  

Streptococcus pneumoniae

1

  

Streptococcus viridans

1

  
  1. CRP C-reactive protein
  2. aIn this group, only patients with bacterial isolates that met all the following criteria were included: (1) the isolates were clinically assumed to be causative strains for the patients’ infection, (2) all assumed causative strains were bacteria and were sensitive to PIP-TAZ, (3) but not to other antibiotic substances given to the patient
  3. bOnly one piperacillin trough level used per day