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Fig. 1 | Critical Care

Fig. 1

From: The role of neutrophils in immune dysfunction during severe inflammation

Fig. 1

Downregulation of immune receptors by serine proteases from degranulated neutrophils and desensitisation by pattern recognition receptors. a Schematic representation of downregulation of receptors on neutrophils, monocytes and lymphocytes during inflammation due to cleavage by neutrophil serine proteases after degranulation. Binding of C5a to neutrophils results in internalisation of C5aR. Decreased expression of these receptors impairs neutrophil effector functions during subsequent challenges. b Biological mimicry between DAMPs and MAMPs. Danger signals derived from necrotic tissue cells ("First hit") bind to pattern recognition receptors (PRRs) and limit subsequent responses to microbial signals ("Second hit") through homo- and heterologous desensitisation. DAMP damage-associated molecular pattern, IL interleukin, MAMP microbe-associated molecular pattern

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