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Table 1 Baseline characteristics of the study patientsa

From: Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial

 

Thiamine (n = 31)

Placebo (n = 33)

Demographics

  

 Age (years)

71 (67, 75)

73 (68, 79)

 Sex (female)

6 (19)

10 (30)

 Body mass index (kg/m2)

29 (26, 33)

28 (25, 29)

 Race

  

 White

31 (100)

32 (97)

 Black

0 (0)

1 (3)

EuroSCORE II (%)

3.4 (2.1, 5.2)

2.3 (1.9, 4.5)

EuroSCORE II > 4.0 %

9 (29)

12 (36)

Cardiac past medical history

  

 MI/PCI

14 (45)

12 (36)

 Atrial fibrillation

7 (23)

5 (15)

 Previous cardiac surgery

0 (0)

2 (6)

 Chronic heart failure

4 (13)

8 (24)

 Valve disease

12 (39)

8 (24)

Ejection fraction (%)

53 (40, 60)

55 (45, 60)

Current NYHA classb

  

 I

5 (16)

1 (3)

 II

12 (29)

14 (42)

 III

14 (45)

15 (45)

 IV

0 (0)

3 (9)

Current angina classb

  

 No symptoms

13 (42)

14 (42)

 I

0 (0)

1 (3)

 II

3 (10)

5 (15)

 III

7 (23)

7 (21)

 IV

8 (26)

8 (18)

Other past medical history

  

 Pulmonary disease

3 (10)

5 (15)

 Diabetes

14 (45)

14 (42)

  Insulin dependent

7 (50)

6 (43)

  Non-insulin dependent

7 (50)

8 (57)

 Renal disease

7 (23)

11 (33)

 Cancer

1 (3)

2 (6)

Pre-operative laboratory values

  

 White blood count (×103)

8.2 (6.8, 8.9)

7.5 (5.7, 10.0)

 Hemoglobin (g/dL)

12.9 (11.5, 14.4)

13.0 (11.2, 14.2)

 Creatinine (mg/dL)

1.1 (0.8, 1.6)

1.1 (0.8, 1.3)

 Glucose (mg/dL)

131 (108, 164)

114 (94, 145)

Pre-surgical characteristics

  

 Status

  

  Elective

14 (45)

12 (36)

  Urgent

17 (55)

21 (65)

 Location prior to surgery

  

  Home

13 (42)

9 (27)

  Ward

15 (48)

24 (73)

  Intensive care unit

3 (10)

0 (0)

  1. Abbreviations: EuroSCORE European System for Cardiac Operative Risk Evaluation, MI myocardial infarction, PCI percutaneous coronary intervention, NYHA New York Heart Association
  2. aCategorical variables are presented as count (frequency) and continuous variables as median (quartiles)
  3. bDefined as the worst classification within the last 2 weeks