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Fig. 1 | Critical Care

Fig. 1

From: Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial

Fig. 1

Simplified graphical presentation of PDH’s and thiamine’s role in aerobic metabolism. Aerobic metabolism occurs when pyruvate enters the mitochondria through pyruvate decarboxylation to acetyl-coenzyme A, facilitated by the rate-limiting enzyme pyruvate dehydrogenase (PDH). Adapted with permission from Andersen et al. [12]. ATP adenosine triphosphate, CoA coenzyme A, TCA tricarboxylic acid

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