All N = 821 | Lactate(24 h) <2 mmol/l | Lactate(24 h) <2 mmol/l | Lactate(24 h) ≥2 mmol/l | Lactate(24 h) ≥2 mmol/l | p value* | |
---|---|---|---|---|---|---|
MAP(24 h) <65 mmHg | MAP(24 h) ≥65 mmHg | MAP(24 h) <65 mmHg | MAP(24 h) ≥65 mmHg | |||
N = 68 | N = 406 | N = 115 | N = 232 | |||
Male (%) | 532/821 (64.8) | 45/68 (66.2) | 274/406 (67.5) | 77/115 (67.0) | 136/232 (58.6) | 0.15 |
Age (years) | 64.0 (14.4) | 68.7 (12.1) | 62.8 (14.4) | 68.2 (11.3) | 62.5 (15.8) | 0.001 |
MAP(adm) | 76.9 (21) | 64.8 (14) | 83.2 (21) | 62.6 (14) | 76.5 (22) | 0.001 |
MAP(24 h) | 72.7 (10) | 61.6 (2.9) | 77.3 (9.4) | 60.2 (4.4) | 73.9 (8.1) | 0.001 |
Lactate(adm) | 1.9 (1.2–3.5) | 1.3 (1.1–1.9) | 1.3 (1.0–1.7) | 4.2 (2.7–6.6) | 3.5 (2.6–5.2) | 0.001 |
Lactate(24 h) | 1.8 (1.2–2.8) | 1.3 (1.1–1.8) | 1.3 (1.1–1.6) | 3.9 (2.7–6.2) | 2.9 (2.3–4.1) | 0.001 |
ScvO2(adm) | 66.4 (11) | 76.4 (3.3) | 68.3 (9.0) | 63.9 (11) | 64.7 (13) | 0.50 |
ScvO2(24 h) | 69.3 (9.4) | 71.1 (11) | 71.3 (8.6) | 68.4 (7.6) | 67.3 (9.9) | 0.063 |
Delta-T(adm) | 6.6 (4.2–9.3) | 7.2 (3.2–10) | 5.9 (3.9–8.8) | 7.4 (5.1–9.7) | 7.4 (4.8–9.9) | 0.007 |
Delta-T(24 h) | 3.7 (2.8–5.1) | 3.4 (2.7–4.9) | 3.3 (2.5–4.5) | 4.5 (3.3–6.1) | 4.0 (3.1–5.8) | 0.001 |
24-h fluid balance (ml) | 3366 (1314–5568) | 4321 (2160–5939) | 2238 (825–3973) | 7080 (3671–9795) | 3932 1722–6277) | 0.001 |
Mechanical ventilation (%) at any time during ICU stay | 627/821 (76) | 52/68 (76.5) | 304/406 (74.9) | 95/115 (82.6) | 176/232 (75.9) | 0.39 |
P/F ratio (lowest during ICU stay) | 156 (105–226) | 169 (117–232) | 160 (107–220) | 140 (89–202) | 166 (105–257) | 0.04 |
Noradrenalin dosea (mg) | 0.0 (0–4.2) | 0.57 (0–4.8) | 0.0 (0–0.85) | 7.4 (0.98-19.2) | 0.72 (0–6.9) | 0.001 |
Dopamine dosea (mg) | 215 (59–469) | 402 (230–727) | 172 (0–320) | 515 (231–912) | 219 (62–473) | 0.001 |
History of arterial hypertension | 237/821 (28.9) | 18/68 (26.5) | 131/406 (32.3) | 34/115 (29.6) | 54/232 (23.3) | 0.11 |
CRRTb (%) | 121/821 (14.7) | 12/68 (17.6) | 22/406 (5.4) | 49/115 (42.6) | 38/232 (16.4) | 0.001 |
SOFA admission | 7.8 (3.7) | 8.1 (3.2) | 6.5 (2.7) | 10.9 (4.5) | 8.7 (3.8) | 0.001 |
APACHE IV predicted mortality | 0.34 (0.16–0.60) | 0.37 (0.19–0.57) | 0.25 (0.13–0.45) | 0.63 (0.37–0.84) | 0.37 (0.18–0.67) | 0.001 |
Length of ICU stay in hours | 86.0 (40.0–209) | 96.5 (47.8–254) | 72 (39.0–189) | 120 (64.0–283) | 80.5 (36.0–199) | 0.013 |
ICU mortality (%) | 146/821 (17.8) | 13/68 (19.1) | 37/406 (9.1) | 51/115 (44.3) | 45/232 (19.4) | 0.001 |
Hospital mortality (%) | 215/821 (26.2) | 18/68 (26.5) | 64/406 (15.8) | 62/115 (53.9) | 71/232 (30.6) | 0.001 |