Endothelial permeability following coronary artery bypass grafting: an observational study on the possible role of angiopoietin imbalance

Table 2 Influence of the 24-h ANG2/ANG1 ratio

Variable	ANG2/ANG1	ANG2/ANG1	p value
Variable	<0.18	>0.18	p value
Details of patients and procedure
Preoperative ejection fraction, %	60 (53–67)	50 (44–55)	0.01
CPB time, minutes	113 (90–125)	110 (103–125)	0.49
Aortic cross-clamp/reperfusion time, minutes	105 (85–120)	105 (93–115)	0.9
Postoperative details (T₂₄)
PaO₂/FiO₂ ratio	407 (360–502)	429 (182–481)	0.79
Lactate, mmol/l	1.27 (1–1.4)	1.32 (1.1–1.2)	0.68
Hgb, mmol/l	9.7 (9.3–10.4)	10.2 (9.1–11.6)	0.52
Crystalloid fluid balance, ml	3100 (2340–3735)	4830 (3310–5720)	0.01
Serum creatinine, mg/dl	1.03 (0.9–1.12)	0.98 (0.74–1.19)	0.58
Duration of mechanical ventilation, h	16.5 (10.3–18.9)	18.8 (17.1–20.2)	0.12
ICU LOS, h	22.2 (21–35.4)	44.4 (21.3–74.6)	0.2
LOS hospital, days	14 (9–15)	14 (11–21)	0.12

The study population was divided into two groups according to the angiopoietin (ANG)2/ANG1 ratio measured 24 h after aortic de-clamping using the overall median ratio (0.18) as threshold value. Details are presented for patients, procedures, and postoperative variables recorded 24 h after admission to ICU (T ₂₄). Median with percentile 25–75, two-tailed Mann–Whitney test. CPB cardiopulmonary bypass, PaO ₂ arterial oxygen partial pressure, FiO ₂ inspiratory oxygen fraction, Hgb hemoglobin, ICU LOS length of stay on intensive care unit, LOS hospital length of stay in hospital

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