Table 4 Risk factors for death at 28 days in the subpopulation with candidemia (univariate analysis)
Variable | Dead (n = 39 patients) | Alive (n = 57 patients) | P value |
|---|---|---|---|
Age, median (IQR) | 64 (50–76) | 57 (46–71) | 0.318 |
SAPS II, median (IQR) | 52 (43–63) | 47 (37–63) | 0.095 |
Male, n (%) | 28 (71.8) | 37 (64.9) | 0.448 |
Medical admission, n (%) | 30 (76.9) | 31 (54.4) | 0.038 |
Charlson comorbidity index score, n (%) | 0.5816 | ||
0 | 8 (20.5) | 17 (29.8) | |
1–2 | 17 (43.6) | 20 (35.1) | |
≥3 | 14 (35.9) | 20 (35.1) | |
At least one chronic illness, n (%) | 16 (41) | 24 (42.1) | 0.982 |
Immunosuppression, n (%) | 8 (20.5) | 7 (12.3) | 0.271 |
Cardiovascular, n (%) | 3 (7.7) | 11 (19.3) | 0.1245 |
Respiratory, n (%) | 5 (12.8) | 7 (12.3) | 0.811 |
Renal, n (%) | 2 (5.1) | 6 (10.5) | 0.431 |
Liver, n (%) | 3 (7.7) | 1 (1.8) | 0.174 |
At least one organ dysfunction on admission, n (%) | 37 (94.9) | 49 (86) | 0.187 |
Cardiovascular, n (%) | 25 (64.1) | 36 (63.2) | 0.901 |
Respiratory, n (%) | 34 (87.2) | 45 (78.9) | 0.284 |
Neurologic, n (%) | 13 (33.3) | 15 (26.3) | 0.375 |
Renal, n (%) | 9 (23.1) | 15 (26.3) | 0.752 |
Delay between ICU admission and fungemia, days, median (IQR) | 8 (4–13) | 10 (3–21) | 0.229 |
Delay between hospital admission and fungemia, days, median (IQR) | 20 (10–29) | 21 (11–32) | 0.591 |
Sepsis syndrome, n (%) | 0.301 | ||
Sepsis | 3 (7.7) | 11 (19.3) | |
Severe sepsis | 14 (35.9) | 20 (35.1) | |
Septic shock | 22 (56.4) | 26 (45.6) | |
SOFA, n (%) | 0.004 | ||
0–4 | 3 (7.7) | 14 (24.6) | |
5–7 | 6 (15.4) | 18 (31.6) | |
8–11 | 12 (30.8) | 19 (33.3) | |
≥12 | 18 (46.2) | 6 (10.5) | |
SOFA score, respiratory, n (%) | 0.019 | ||
0 | 4 (10.3) | 8 (14) | |
1 | 1 (2.6) | 7 (12.3) | |
2 | 8 (20.5) | 23 (40.4) | |
3 | 13 (33.3) | 16 (28.1) | |
4 | 13 (33.3) | 3 (5.3) | |
SOFA score, cardiovascular, n (%) | 0.015 | ||
0 | 9 (23.1) | 19 (33.3) | |
1 | 4 (10.3) | 12 (21.1) | |
2 | 1 (2.6) | 4 (7) | |
3 | 4 (10.3) | 13 (22.8) | |
4 | 21 (53.8) | 9 (15.8) | |
SOFA score, neurological, n (%) | 0.249 | ||
0 | 13 (33.3) | 17 (29.8) | |
1 | 5 (12.8) | 14 (24.6) | |
2 | 7 (17.9) | 8 (14) | |
3 | 4 (10.3) | 11 (19.3) | |
4 | 10 (25.6) | 7 (12.3) | |
SOFA score, renal, n (%) | 0.122 | ||
0 | 11 (28.2) | 32 (56.1) | |
1 | 8 (20.5) | 10 (17.5) | |
2 | 5 (12.8) | 5 (8.8) | |
3 | 5 (12.8) | 3 (5.3) | |
4 | 10 (25.6) | 7 (12.3) | |
SOFA score, coagulation, n (%) | 0.125 | ||
0 | 19 (48.7) | 42 (73.7) | |
1 | 6 (15.4) | 3 (5.3) | |
2 | 4 (10.3) | 7 (12.3) | |
3 | 6 (15.4) | 4 (7) | |
4 | 4 (10.3) | 1 (1.8) | |
SOFA score, liver, n (%) | 0.142 | ||
0 | 26 (66.7) | 46 (80.7) | |
1 | 6 (15.4) | 6 (10.5) | |
2 | 1 (2.6) | 4 (7) | |
3 | 6 (15.4) | 1 (1.8) | |
Need for mechanical ventilation, n (%) | 37 (94.9) | 47 (82.5) | 0.094 |
Hypotension, n (%) | 25 (64.1) | 29 (50.9) | 0.208 |
Presumed source of infection, n (%) | 0.573 | ||
No clear source | 12 (30.8) | 20 (35.1) | |
Catheter-related | 6 (15.4) | 15 (26.3) | |
Intra-abdominal | 8 (20.5) | 4 (7) | |
Respiratory | 6 (15.4) | 8 (14) | |
Urinary | 2 (5.1) | 2 (3.5) | |
Others | 2 (5.1) | 4 (7) | |
Multiple sources, n (%) | 3 (7.7) | 4 (7) | |
Delay of adequate treatment, n (%) | 0.694 | ||
<24 h | 11 (28.2) | 11 (19.3) | |
>24 h and ≤48 h | 9 (23.1) | 14 (24.6) | |
>48 h and ≤120 h | 12 (30.8) | 24 (42.1) | |
>120 h or never | 7 (17.9) | 8 (14) | |
Antifungal treatment on the day of blood culture sampling, n (%) | 8 (20.5) | 8 (14) | 0.491 |
Candida pathogen, n (%) | 0.693 | ||
Candida albicans | 23 (59) | 33 (57.9) | |
Candida parapsilosis | 5 (12.8) | 5 (8.8) | |
Other fungus | 11 (28.2) | 19 (33.3) |