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Table 4 Risk factors for death at 28 days in the subpopulation with candidemia (univariate analysis)

From: Characteristics and risk factors for 28-day mortality of hospital acquired fungemias in ICUs: data from the EUROBACT study

Variable Dead (n = 39 patients) Alive (n = 57 patients) P value
Age, median (IQR) 64 (50–76) 57 (46–71) 0.318
SAPS II, median (IQR) 52 (43–63) 47 (37–63) 0.095
Male, n (%) 28 (71.8) 37 (64.9) 0.448
Medical admission, n (%) 30 (76.9) 31 (54.4) 0.038
Charlson comorbidity index score, n (%)    0.5816
 0 8 (20.5) 17 (29.8)  
 1–2 17 (43.6) 20 (35.1)  
 ≥3 14 (35.9) 20 (35.1)  
At least one chronic illness, n (%) 16 (41) 24 (42.1) 0.982
 Immunosuppression, n (%) 8 (20.5) 7 (12.3) 0.271
 Cardiovascular, n (%) 3 (7.7) 11 (19.3) 0.1245
 Respiratory, n (%) 5 (12.8) 7 (12.3) 0.811
 Renal, n (%) 2 (5.1) 6 (10.5) 0.431
 Liver, n (%) 3 (7.7) 1 (1.8) 0.174
At least one organ dysfunction on admission, n (%) 37 (94.9) 49 (86) 0.187
 Cardiovascular, n (%) 25 (64.1) 36 (63.2) 0.901
 Respiratory, n (%) 34 (87.2) 45 (78.9) 0.284
 Neurologic, n (%) 13 (33.3) 15 (26.3) 0.375
 Renal, n (%) 9 (23.1) 15 (26.3) 0.752
Delay between ICU admission and fungemia, days, median (IQR) 8 (4–13) 10 (3–21) 0.229
Delay between hospital admission and fungemia, days, median (IQR) 20 (10–29) 21 (11–32) 0.591
Sepsis syndrome, n (%)    0.301
 Sepsis 3 (7.7) 11 (19.3)  
 Severe sepsis 14 (35.9) 20 (35.1)  
 Septic shock 22 (56.4) 26 (45.6)  
SOFA, n (%)    0.004
 0–4 3 (7.7) 14 (24.6)  
 5–7 6 (15.4) 18 (31.6)  
 8–11 12 (30.8) 19 (33.3)  
 ≥12 18 (46.2) 6 (10.5)  
SOFA score, respiratory, n (%)    0.019
 0 4 (10.3) 8 (14)  
 1 1 (2.6) 7 (12.3)  
 2 8 (20.5) 23 (40.4)  
 3 13 (33.3) 16 (28.1)  
 4 13 (33.3) 3 (5.3)  
SOFA score, cardiovascular, n (%)    0.015
 0 9 (23.1) 19 (33.3)  
 1 4 (10.3) 12 (21.1)  
 2 1 (2.6) 4 (7)  
 3 4 (10.3) 13 (22.8)  
 4 21 (53.8) 9 (15.8)  
SOFA score, neurological, n (%)    0.249
 0 13 (33.3) 17 (29.8)  
 1 5 (12.8) 14 (24.6)  
 2 7 (17.9) 8 (14)  
 3 4 (10.3) 11 (19.3)  
 4 10 (25.6) 7 (12.3)  
SOFA score, renal, n (%)    0.122
 0 11 (28.2) 32 (56.1)  
 1 8 (20.5) 10 (17.5)  
 2 5 (12.8) 5 (8.8)  
 3 5 (12.8) 3 (5.3)  
 4 10 (25.6) 7 (12.3)  
SOFA score, coagulation, n (%)    0.125
 0 19 (48.7) 42 (73.7)  
 1 6 (15.4) 3 (5.3)  
 2 4 (10.3) 7 (12.3)  
 3 6 (15.4) 4 (7)  
 4 4 (10.3) 1 (1.8)  
SOFA score, liver, n (%)    0.142
 0 26 (66.7) 46 (80.7)  
 1 6 (15.4) 6 (10.5)  
 2 1 (2.6) 4 (7)  
 3 6 (15.4) 1 (1.8)  
Need for mechanical ventilation, n (%) 37 (94.9) 47 (82.5) 0.094
Hypotension, n (%) 25 (64.1) 29 (50.9) 0.208
Presumed source of infection, n (%)    0.573
 No clear source 12 (30.8) 20 (35.1)  
 Catheter-related 6 (15.4) 15 (26.3)  
 Intra-abdominal 8 (20.5) 4 (7)  
 Respiratory 6 (15.4) 8 (14)  
 Urinary 2 (5.1) 2 (3.5)  
 Others 2 (5.1) 4 (7)  
 Multiple sources, n (%) 3 (7.7) 4 (7)  
Delay of adequate treatment, n (%)    0.694
 <24 h 11 (28.2) 11 (19.3)  
 >24 h and ≤48 h 9 (23.1) 14 (24.6)  
 >48 h and ≤120 h 12 (30.8) 24 (42.1)  
 >120 h or never 7 (17.9) 8 (14)  
Antifungal treatment on the day of blood culture sampling, n (%) 8 (20.5) 8 (14) 0.491
Candida pathogen, n (%)    0.693
 Candida albicans 23 (59) 33 (57.9)  
 Candida parapsilosis 5 (12.8) 5 (8.8)  
 Other fungus 11 (28.2) 19 (33.3)  
  1. SOFA Sequential Organ Failure Assessment