Easily identified at-risk patients for extubation failure may benefit from noninvasive ventilation: a prospective before-after study

Table 3 Variables independently associated with reintubation within the 7 days following extubation in patients at high-risk for extubation failure (N = 233)

Multivariate analysis using logistic regression	Adjusted Odds Ratio^a [95 % CI]	P value
Duration of MV prior to extubation, per day	1.09 [1.05–1.13]	<0.001
Use of prophylactic NIV protocol	0.48 [0.24–0.96]	0.04

All variables significantly associated with extubation failure with a p value < 0.15 were included in the model including: male sex, SAPS II, hypercapnia, duration of mechanical ventilation (MV) prior to extubation, and application of prophylactic NIV protocol (NIV cohort)
SAPS II Simplified Acute Physiology Score II, NIV noninvasive positive pressure ventilation
^aValues of adjusted odds ratio are taken from the final model including only variables independently associated with extubation failure. Logistic regression was performed using 233 observations and the final model had an area under a Receiver Operating Curve of 0.726 (Hosmer-Lemeshow test 0.683)

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