Table 2 Variables associated with reintubation within the 7 days following extubation among all patients at high-risk for extubation failure

 Age, years

68 ± 14

69 ± 10

0.46

 Age ≥ 65 years, n (%)

128 (68 %)

35 (76 %)

0.31

 Male sex, n (%)

103 (55 %)

31 (67 %)

0.13

 SAPS II at admission, points

48 ± 18

53 ± 19

0.13

 Underlying cardiac disease, n (%)

107 (57 %)

28 (60 %)

0.65

 Underlying chronic lung disease, n (%)

69 (37 %)

15 (33 %)

0.59

Use of prophylactic NIV protocol

127 (68 %)

23 (50 %)

0.02

Reason for intubation

0.40

 Acute respiratory failure, n (%)

78 (42 %)

19 (41 %)

 Shock, n (%)

38 (20 %)

5 (11 %)

 Coma or neurologic disorders, n (%)

31 (17 %)

7 (15 %)

 Postoperative, n (%)

34 (18 %)

12 (26 %)

 Cardiac arrest, n (%)

6 (3 %)

3 (7 %)

 SOFA at time of extubation, points

3.4 ± 2.2

3.7 ± 2.7

0.46

 PaO₂/FiO₂ ratio, mm Hg

289 ± 90

300 ± 103

0.47

 PaO₂/FiO₂ ratio ≤ 200 mm Hg, n (%)

30 (16 %)

6 (13 %)

0.61

 pH, units

7.45 ± 0.06

7.46 ± 0.06

0.63

 PaCO₂, mm Hg

41 ± 9

38 ± 8

0.16

 PaCO₂ > 45 mm Hg, n (%)

42 (23 %)

9 (20 %)

0.67

 Duration of MV prior to extubation, days

6.0 [4.0–11.0]

13.0 [5.0–20.0]

<0.001

 Duration of MV prior to extubation > 7 days, n (%)

77 (41 %)

29 (63 %)

<0.01