Diagnosis and prognosis of neutrophil gelatinase-associated lipocalin for acute kidney injury with sepsis: a systematic review and meta-analysis

Table 3 Diagnostic value of NGAL to predict AKI in septic patients in individual studies

Study	AUC	95 % CI	Cutoff value	Sensitivity (%)	Specificity (%)	Number of patients
Study	AUC	95 % CI	Cutoff value	Sensitivity (%)	Specificity (%)	TP rate	FP rate	FN rate	TN rate
Aydogdu et al. [21]	0.80	NR	29.5 ng/ml	0.88	0.73	55	18	8	48
Camou et al. [31]	0.90	NR	150 ng/ml	0.93	0.44	40	4	3	3
de Geus et al. [34]	0.80	0.69–0.88	304 ng/ml	0.8	0.80	40	5	10	20
Fan et al. [30]	0.86	0.81-0.93	NR	0.89	0.74	52	18	6	50
Hjortrup et al. [29] (p)	0.66	0.54–0.77	NR	0.58	0.76	18	22	13	71
Hjortrup et al. [29] (u)	0.71	0.59–0.82	NR	0.56	0.72	14	21	11	54
Li and Xu [22]	0.94	0.68-0.97	50 μg/l	0.94	0.88	16	7	1	50
Martensson et al. [33] (p)	0.85	0.39-0.94	>120 ng/ml	0.83	0.86	15	4	3	23
Martensson et al. [33] (u)	0.86	0.68-1.00	>68 ng/mg.scr	0.71	1.00	13	0	5	27
Niu et al. [23]	0.91	NR	52 μg/g · scr	0.88	0.87	23	5	3	29
Shapiro et al. [24]	0.82	0.76-0.88	NR	0.96	0.51	23	312	1	325
Si et al. [32]	0.73	0.64-0.82	3.36 ng/ml	0.63	0.46	76	25	45	22
Wang et al. [25]	0.81	0.71-0.91	150 ng/ml	0.79	0.90	26	5	7	49
Xing et al. [26] (p)	0.86	0.77-0.94	92.5 ng/ml	0.85	0.87	30	5	5	33
Xing et al. [26] (u)	0.93	0.88-0.93	118.5 ng/ml	0.93	0.89	32	4	3	34
Yan et al. [27]	0.93	0.88-0.98	65 μg/l	0.95	0.86	54	8	3	47
Yan and Xang [28]	0.86	0.70-0.96	90 μg/l	0.87	0.86	38	14	6	83
Zhou et al. [35]	0.80	0.7 l-0.93	85 ng/l	0.78	0.80	36	20	10	82

AKI acute kidney injury, AUC area under the curve, CI confidence interval, FP false-positive, FN false-negative, NGAL neutrophil gelatinase-associated lipocalin, NR not reported, p plasma, TP true-positive, TN true-negative, u urine

ISSN: 1364-8535