Skip to main content

Table 3 Time course of ventilation variables, blood gases, ECCO2R operational characteristics and hemodynamics at VT 4 mL/kg plus ECCO2R

From: Feasibility and safety of low-flow extracorporeal carbon dioxide removal to facilitate ultra-protective ventilation in patients with moderate acute respiratory distress syndrome

Variables Baseline   VT 4 mL/kg plus ECCO2R
   Day 1 Day 2 Day 3
Time (h) 8.00 8.00 8.00 20.00 8.00 20.00
Patients (number) 15 15 10 10 8 6
VT (mL/kg) 6.2 ± 0.7 4.29 ± 0.5* 4.58 ± 0.7* 4.59 ± 0.8* 4.8 ± 0.7* 4.8 ± 0.7*
Respiratory rate (beats/minute) 28 ± 7 31.6 ± 4.6* 29.6 ± 6.8 29.6 ± 6.8 28 ± 7 27.4 ± 8.6
Positive end-expiratory pressure (cmH2O) 12 ± 3 14 ± 2 13 ± 3 12 ± 4 13 ± 5 13 ± 3
Arterial partial pressure of oxygen/inspired oxygen fraction 159 ± 34 175 ± 45 185 ± 91 190 57 176 ± 59 176 ± 80
Plateau pressure (cmH2O) 27.7 ± 1.6 23.9 ± 1* 24 ± 4* 24 ± 3* 24 ± 3* 23 ± 3*
Blood flow (ml/min)   435 ± 60 424 ± 63 423 ± 35 424 ± 29 436 ± 39
Rotations per minute (RPM)   1407 ± 26 1408 ± 30 1409 ± 32 1411 ± 36 1414 ± 41
Sweep gas (L/min)   8.6 ± 3.5 9.2 ± 2.9 9 ± 3 9.9 ± 0.3 8.7 ± 3.2
CO2 removal (ml/min)   81 ± 9 70 ± 29 70 ± 31 81 ± 22 71 ± 11
Ph 7.36 ± 0.1 7.33 ± 0.1 7.39 ± 0.1 7.36 ± 0.1 7.33 ± 0.1 7.4 ± 0.1
PaO2 (mmHg) 95 ± 29 90 ± 22 91 ± 26 84 ± 10 81 ± 15 99 ± 29
PaCO2 (mmHg) 51 ± 15 53 ± 15 51 ± 18 52 ± 17 55 ± 20 49 ± 11
HCO3 (mmol/L) 28 ± 5 27.6 ± 6.1 28.7 ± 6.2 28. ± 6.9 28.1 ± 7.4 28.3 ± 6.03
Lactate (mmol/L) 2 ± 1 2.9 ± 4.8 1.9 ± 1.7 1.8 ± 1.8 1.9 ± 2.0 1.3 ± 0.4
Heart rate (beats/minute) 76 ± 9 90 ± 17 86 ± 15 95 ± 21 94 ± 19 94 ± 17
Mean arterial pressure (mmHg) 98 ± 20 74 ± 14 80 ± 10 76 ± 12 76 ± 19 85 ± 14
Norepinephrine dose (mcg/kg/min) 0.51 ± 0.6 0.45 ± 0.4 0.34 ± 0.3 0.29 ± 0.27 0.57 ± 0.4 0.5 ± 0.6
  1. *P <0.05 vs baseline. V T tidal volume, ECCO 2 R extracorporeal carbon dioxide removal