Table 3 Time course of ventilation variables, blood gases, ECCO₂R operational characteristics and hemodynamics at V_T 4 mL/kg plus ECCO₂R

Time (h)

8.00

8.00

8.00

20.00

8.00

20.00

Patients (number)

15

15

10

10

8

6

V_T (mL/kg)

6.2 ± 0.7

4.29 ± 0.5*

4.58 ± 0.7*

4.59 ± 0.8*

4.8 ± 0.7*

4.8 ± 0.7*

Respiratory rate (beats/minute)

28 ± 7

31.6 ± 4.6*

29.6 ± 6.8

29.6 ± 6.8

28 ± 7

27.4 ± 8.6

Positive end-expiratory pressure (cmH₂O)

12 ± 3

14 ± 2

13 ± 3

12 ± 4

13 ± 5

13 ± 3

Arterial partial pressure of oxygen/inspired oxygen fraction

159 ± 34

175 ± 45

185 ± 91

190 57

176 ± 59

176 ± 80

Plateau pressure (cmH₂O)

27.7 ± 1.6

23.9 ± 1*

24 ± 4*

24 ± 3*

24 ± 3*

23 ± 3*

Blood flow (ml/min)

435 ± 60

424 ± 63

423 ± 35

424 ± 29

436 ± 39

Rotations per minute (RPM)

1407 ± 26

1408 ± 30

1409 ± 32

1411 ± 36

1414 ± 41

Sweep gas (L/min)

8.6 ± 3.5

9.2 ± 2.9

9 ± 3

9.9 ± 0.3

8.7 ± 3.2

CO₂ removal (ml/min)

81 ± 9

70 ± 29

70 ± 31

81 ± 22

71 ± 11

Ph

7.36 ± 0.1

7.33 ± 0.1

7.39 ± 0.1

7.36 ± 0.1

7.33 ± 0.1

7.4 ± 0.1

PaO2 (mmHg)

95 ± 29

90 ± 22

91 ± 26

84 ± 10

81 ± 15

99 ± 29

PaCO2 (mmHg)

51 ± 15

53 ± 15

51 ± 18

52 ± 17

55 ± 20

49 ± 11

HCO3 (mmol/L)

28 ± 5

27.6 ± 6.1

28.7 ± 6.2

28. ± 6.9

28.1 ± 7.4

28.3 ± 6.03

Lactate (mmol/L)

2 ± 1

2.9 ± 4.8

1.9 ± 1.7

1.8 ± 1.8

1.9 ± 2.0

1.3 ± 0.4

Heart rate (beats/minute)

76 ± 9

90 ± 17

86 ± 15

95 ± 21

94 ± 19

94 ± 17

Mean arterial pressure (mmHg)

98 ± 20

74 ± 14

80 ± 10

76 ± 12

76 ± 19

85 ± 14

Norepinephrine dose (mcg/kg/min)

0.51 ± 0.6

0.45 ± 0.4

0.34 ± 0.3

0.29 ± 0.27

0.57 ± 0.4

0.5 ± 0.6