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Table 1 Baseline characteristics for the entire cohort of patients with necrotizing soft tissue infections and for the septic shock and nonshock (no sepsis, sepsis, severe sepsis) subgroups

From: Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study

  Entire cohort (n = 135) Nonshock (n = 39) Septic shock (n = 96) p
Age, years 61 (52–69) 58 (48–70) 62 (54–69) 0.426
Sex, male 84 (62) 24 (62) 60 (63) 0.917
Body mass index, kg/m2 26 (23–31) 24 (22–31) 27 (25–32) 0.017
Chronic disease
 Chronic disease 86 (64) 28 (72) 58 (60) 0.213
  Diabetes 30 (22) 10 (26) 20 (21) 0.543
  Liver cirrhosis 5 (4) 1 (3) 4 (4) 0.655
  Chronic kidney disease 12 (9) 6 (15) 6 (6) 0.104
  Cardiovascular disease 58 (43) 21 (54) 37 (39) 0.103
  Chronic obstructive pulmonary disease 14 (10) 3 (8) 11 (12) 0.757
  Peripheral vascular disease 20 (15) 8 (21) 12 (13) 0.235
  Immune deficiency/AIDS 3 (2) 2 (5) 1 (1) 0.200
  Malignancy 15 (11) 3 (8) 12 (13) 0.553
  Rheumatoid disease 10 (7) 2 (5) 8 (8) 0.723
 Active smoker 40 (30) 9 (23) 31 (32) 0.366
 High alcohol consumptiona 19 (14) 3 (8) 16 (17) 0.191
 Steroid treatment 16 (12) 4 (10) 12 (13) 0.277
 Immunosuppressing drugs 12 (9) 3 (8) 9 (9) 0.281
Primary site of infection
 Head/neck 21 (15) 6 (16) 15 (16) 0.972
 Upper extremity 15 (11) 3 (8) 12 (13) 0.553
 Lower extremity 47 (35) 13 (33) 34 (35) 0.818
 Chest 5 (4) 2 (5) 3 (3) 0.626
 Abdomen 11 (8) 2 (5) 9 (9) 0.510
 Genital/perineum 36 (27) 13 (33) 23 (24) 0.264
Microorganism
 Positive cultures 100 (74) 25 (64) 75 (78) 0.128
 Polymicrobial 54 (40) 13 (33) 41 (43) 0.339
 Beta-hemolytic streptococcus 46 (34) 9 (23) 37 (39) 0.120
 Staphylococcus aureus 14 (10) 2 (5) 12 (13) 0.350
 Anaerobes 23 (17) 9 (23) 14 (15) 0.312
 Gram negative rods 25 (19) 6 (15) 19 (20) 0.632
 Other 15 (11) 5 (13) 10 (10) 0.764
  1. Values denote median (interquartile range) or number (%). Differences between the shock and nonshock group were tested using Mann-Whitney U or χ2-test/Fisher’s exact test
  2. aHigh alcohol consumption: >14 units of alcohol/week (women); >21 units of alcohol/week (men)