Urinary chitinase 3-like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patients

Table 5 Comparison of AUC-ROC between the two-biomarker panel [urinary chitinase 3-like protein 1]•[urinary neutrophil gelatinase-associated lipocalin] and each of these single biomarkers

Two-biomarker panel	Time window	AKI_SCr/UO stage ≥2^a			AKI_SCr stage ≥2^b
Two-biomarker panel	Time window	AUC-ROC	95 % CI	P value	AUC-ROC	95 % CI	P value
Enrollment [UCHI3L1]•[UNGAL]	12 h	0.784	0.717–0.841	0.764^c	0.874	0.817–0.919	0.879^c
Enrollment [UCHI3L1]•[UNGAL]	12 h	0.784	0.717–0.841	0.522^d	0.874	0.817–0.919	0.544^d
	24 h	0.721	0.650–0.785	0.856^c	0.899	0.845–0.939	0.877^c
	24 h	0.721	0.650–0.785	0.622^d	0.899	0.845–0.939	0.311^d

^aBased on the Kidney Disease | Improving Global Outcomes (KDIGO) serum creatinine (SCr) or urine output (UO) criteria for acute kidney injury (AKI). ^bBased on the KDIGO SCr criteria for AKI. ^cDifference in the area under the receiver-operating characteristics curve (AUC-ROC) between the two-biomarker panel and urinary chitinase 3-like protein 1 (UCHI3L1), both measured at enrollment. ^dDifference in AUC-ROC between the two-biomarker panel and urinary neutrophil gelatinase-associated lipocalin (UNGAL), both measured at enrollment

ISSN: 1364-8535