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Table 4 Comparison of areas under the receiver-operating characteristics curves

From: Urinary chitinase 3-like protein 1 for early diagnosis of acute kidney injury: a prospective cohort study in adult critically ill patients

Biomarker measurement

Time window

AKISCr/UO stage ≥ 2a

AKISCr stage ≥ 2b

AUC-ROC

95 % CI

P valuec

AUC-ROC

95 % CI

P valuec

Number = 181

â–“ Enrollment UCHI3L1

12-h

â–“ 0.792

▓ 0.726–0.849

 

â–“ 0.877

▓ 0.820–0.921

 

24-h

â–“ 0.716

▓ 0.644–0.780

 

â–“ 0.901

▓ 0.848–0.940

 

Comparison with

     

Enrollment UCr-corrected UCHI3L1

12-h

0.674

0.601–0.742

0.038

0.832

0.769–0.883

0.359

24-h

0.587

0.511–0.659

0.005

0.861

0.802–0.908

0.308

Enrollment SCHI3L1

12-h

0.645

0.570–0.714

0.071

0.784

0.717–0.842

0.300

24-h

0.548

0.472–0.622

0.022

0.830

0.767–0.881

0.324

Enrollment SCr

12-h

0.624

0.549–0.695

0.113

0.732

0.662–0.795

0.363

24-h

0.639

0.565–0.709

0.406

0.766

0.697–0.826

0.278

Enrollment SCr to reference SCr ratio

12-h

0.690

0.618–0.757

0.274

0.806

0.741–0.861

0.614

24-h

0.695

0.622–0.761

0.784

0.847

0.786–0.896

0.622

â–“ Enrollment UNGAL

12-h

â–“ 0.748

▓ 0.678–0.810

 

â–“ 0.865

▓ 0.807–0.911

 

24-h

â–“ 0.702

▓ 0.630–0.768

 

â–“ 0.886

▓ 0.830–0.928

 

Comparison with

     

Enrollment UCr-corrected UNGAL

12-h

0.622

0.547–0.693

0.007

0.795

0.729–0.851

0.123

24-h

0.570

0.495–0.644

0.001

0.826

0.763–0.878

0.109

Number = 180d

â–“ Enrollment UCHI3L1

12-h

â–“ 0.791

▓ 0.724–0.848

 

â–“ 0.876

▓ 0.819–0.921

 

24-h

â–“ 0.715

▓ 0.643–0.779

 

â–“ 0.901

▓ 0.847–0.940

 

Comparison with

     

UO after enrollmente

12-h

0.833

0.771–0.885

0.728

0.759

0.690–0.820

0.034

24-h

0.808

0.743–0.863

0.438

0.795

0.728–0.851

0.022

  1. aBased on the Kidney Disease | Improving Global Outcomes (KDIGO) serum creatinine (SCr) or urine output (UO) criteria for acute kidney injury (AKI). bBased on the KDIGO SCr criteria for AKI. cThe P value is shown for the difference in the area under the receiver-operating characteristics curve (AUC-ROC). We always compared with the AUC-ROC of the urinary biomarker (UCHI3L1 or UNGAL; marked with a shaded rectangle). dUO after enrollment could not be calculated in one patient. eDefined as the mean UO in the first valid 6-h period after enrollment (in ml/kg/h). CI confidence interval, SCHI3L1 serum chitinase 3-like protein 1, UCHI3L1 urinary chitinase 3-like protein 1, UCr urinary creatinine, UNGAL urinary neutrophil gelatinase-associated lipocalin