Table 3 Summary of prespecified adverse events recorded in the ICU

Neutropenia^a <1500/mm³

9 (11)

Delay between cyclophosphamide administration and neutropenia^a <500/mm³, days

16 (2–25)

Number of patients with infection

25 (30)

 Location

 Urinary tract

2 (8)

 Lung

15 (60)

 Bacteremia

4 (16)

 Others

4 (16)

 Bacterial source

  Gram-positive

3 (12)

  Gram-negative

16 (64)

  Other^b

1 (4)

 No pathogen identified

5 (20)

 Delay between ICU admission and first infection event, days

13.0 (4.5–19.75)

 Number of patients with septic shock

13 (16)

Number of patients presenting with hemorrhagic syndrome

57 (69)

 Number of packed red blood cells infused during ICU stay

4.0 (0–7.5)

 Delay between ICU admission and first hemorrhagic event, days

1.0 (0–5.0)

Cause of death in ICU

 Infection

4 (31)

 Disease flare

9 (69)