Fig. 5
From: T cells from patients with Candida sepsis display a suppressive immunophenotype
CD marker expression on CD4 and CD8 T cells related to senescence and inhibitory or stimulatory effects. CD57 is a marker that is used to identify senescent, poorly functional T cells. TIM-3 is a co-inhibitory molecule that impairs T cell function. 2B4 (CD244) is a dual-functional receptor that may have either inhibitory or stimulatory effects on T cells depending upon other stimuli and environmental settings. Horizontal lines indicate mean or median values. Asterisks indicate significant differences between CINS and CBSI (* p ≤0.05 and ** p ≤0.01). CBSI Candida bloodstream infection, CINS critically ill non-sepsis, TIM-3T cell immunoglobulin domain and mucin domain 3