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Table 3 Post-operative outcomes of patients with reference to PCC administration

From: Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery

  Overall series Propensity score–matched pairs
No PCC (n = 680) PCC (n = 291) p Value Propensity score adjusted (OR, 95 % CI or βa, 95 % CI) No PCC (n = 225) PCC (n = 225) p Value
In-hospital mortality 49 (7.2) 24 (8.2) 0.573 1.51, 0.84–2.72 19 (8.4) 21 (9.3) 0.740
Post-operative IABP 81 (11.9) 21 (7.2) 0.029 0.61, 0.35–1.09 32 (14.2) 17 (7.6) 0.023
Inotropes 559 (82.2) 217 (74.6) 0.007 0.74, 0.50–1.08 182 (80.9) 170 (75.6) 0.171
Vasopressors 177 (26.0) 92 (31.6) 0.075 1.18, 0.83–1.67 67 (29.8) 71 (31.6) 0.683
Peri-operative MI 35 (5.1) 14 (4.8) 0.827 1.22, 0.58–2.58 13 (5.8) 12 (5.3) 0.837
Stroke 38 (5.6) 20 (6.9) 0.439 1.19, 0.32–5.21 9 (4.0) 14 (6.2) 0.284
AKI 159 (23.4) 91 (31.3) 0.010 1.44, 1.02–2.05 60 (26.7) 68 (30.2) 0.403
RRT 8 (1.2) 9 (3.1) 0.037 3.35, 1.13–9.90 4 (1.8) 8 (3.6) 0.381
Post-operative AF 338 (49.7) 165 (56.7) 0.046 1.34, 0.97–1.84 124 (55.1) 136 (60.4) 0.252
Resternotomy for bleeding 114 (16.8) 42 (14.4) 0.365 0.95, 0.61–1.47 42 (18.7) 33 (14.7) 0.255
Blood loss, ml 908 ± 625 803 ± 1100 <0.0001 −96.5, −222.1 to −29.0 935 ± 583 836 ± 1226 <0.0001
RBC transfusion 619 (91.0) 243 (83.5) 0.001 0.50, 0.31–0.80 210 (93.3) 189 (84.0) 0.002
RBC transfusion, U 4.9 ± 4.5 3.4 ± 3.0 <0.0001 −1.42, −2.06 to −0.77 5.2 ± 4.3 3.4 ± 3.1 <0.0001
RBC transfusion >2 U 463 (68.1) 154 (52.9) <0.0001 0.53, 0.38–0.73 158 (70.2) 114 (50.7) <0.0001
Platelet transfusion 362 (53.2) 170 (58.4) 0.137 1.27, 0.92–1.75 123 (54.7) 133 (59.1) 0.341
Ventilation, h 82 ± 202 68 ± 99 0.160 −6.09, −34.12 to 21.95 73.2 ± 98.7 68 ± 95 0.871
ICU stay, h 125 ± 175 112 ± 122 0.191 −4.34, −1.49 to 0.63 128 ± 152 110 ± 118 0.954
In-hospital stay, days 13.2 ± 12.1 11.4 ± 7.7 0.589 −1.47, −3.20 to 0.27 14.1 ± 12.9 11.4 ± 7.9 0.115
  1. MI myocardial infarction, AF atrial fibrillation, AKI acute kidney injury, CI confidence interval, IABP intra-aortic balloon pump, ICU intensive care unit, OR odds ratio, PCC prothrombin complex concentrates, RBC red blood cells, RRT renal replacement therapy
  2. Continuous values are reported as mean and standard deviation; nominal variables are reported as counts (percentages)
  3. aβ value represents the β unstandardised coefficient of the linear regression analysis