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Table 3 Post-operative outcomes of patients with reference to PCC administration

From: Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery

 

Overall series

Propensity score–matched pairs

No PCC (n = 680)

PCC (n = 291)

p Value

Propensity score adjusted (OR, 95 % CI or βa, 95 % CI)

No PCC (n = 225)

PCC (n = 225)

p Value

In-hospital mortality

49 (7.2)

24 (8.2)

0.573

1.51, 0.84–2.72

19 (8.4)

21 (9.3)

0.740

Post-operative IABP

81 (11.9)

21 (7.2)

0.029

0.61, 0.35–1.09

32 (14.2)

17 (7.6)

0.023

Inotropes

559 (82.2)

217 (74.6)

0.007

0.74, 0.50–1.08

182 (80.9)

170 (75.6)

0.171

Vasopressors

177 (26.0)

92 (31.6)

0.075

1.18, 0.83–1.67

67 (29.8)

71 (31.6)

0.683

Peri-operative MI

35 (5.1)

14 (4.8)

0.827

1.22, 0.58–2.58

13 (5.8)

12 (5.3)

0.837

Stroke

38 (5.6)

20 (6.9)

0.439

1.19, 0.32–5.21

9 (4.0)

14 (6.2)

0.284

AKI

159 (23.4)

91 (31.3)

0.010

1.44, 1.02–2.05

60 (26.7)

68 (30.2)

0.403

RRT

8 (1.2)

9 (3.1)

0.037

3.35, 1.13–9.90

4 (1.8)

8 (3.6)

0.381

Post-operative AF

338 (49.7)

165 (56.7)

0.046

1.34, 0.97–1.84

124 (55.1)

136 (60.4)

0.252

Resternotomy for bleeding

114 (16.8)

42 (14.4)

0.365

0.95, 0.61–1.47

42 (18.7)

33 (14.7)

0.255

Blood loss, ml

908 ± 625

803 ± 1100

<0.0001

−96.5, −222.1 to −29.0

935 ± 583

836 ± 1226

<0.0001

RBC transfusion

619 (91.0)

243 (83.5)

0.001

0.50, 0.31–0.80

210 (93.3)

189 (84.0)

0.002

RBC transfusion, U

4.9 ± 4.5

3.4 ± 3.0

<0.0001

−1.42, −2.06 to −0.77

5.2 ± 4.3

3.4 ± 3.1

<0.0001

RBC transfusion >2 U

463 (68.1)

154 (52.9)

<0.0001

0.53, 0.38–0.73

158 (70.2)

114 (50.7)

<0.0001

Platelet transfusion

362 (53.2)

170 (58.4)

0.137

1.27, 0.92–1.75

123 (54.7)

133 (59.1)

0.341

Ventilation, h

82 ± 202

68 ± 99

0.160

−6.09, −34.12 to 21.95

73.2 ± 98.7

68 ± 95

0.871

ICU stay, h

125 ± 175

112 ± 122

0.191

−4.34, −1.49 to 0.63

128 ± 152

110 ± 118

0.954

In-hospital stay, days

13.2 ± 12.1

11.4 ± 7.7

0.589

−1.47, −3.20 to 0.27

14.1 ± 12.9

11.4 ± 7.9

0.115

  1. MI myocardial infarction, AF atrial fibrillation, AKI acute kidney injury, CI confidence interval, IABP intra-aortic balloon pump, ICU intensive care unit, OR odds ratio, PCC prothrombin complex concentrates, RBC red blood cells, RRT renal replacement therapy
  2. Continuous values are reported as mean and standard deviation; nominal variables are reported as counts (percentages)
  3. aβ value represents the β unstandardised coefficient of the linear regression analysis