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Table 1 Baseline characteristics of patients with reference to PCC administration

From: Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery

  Overall series Propensity score–matched pairs
  No PCC (n = 680) PCC (n = 291) p Value Pre-match SD No PCC (n = 225) PCC (n = 225) p Value Post-match SD
Age, yr 69.8 ± 10.1 69.0 ± 12.3 0.963 0.006 69.7 ± 10.6 69.2 ± 11.6 0.932 0.004
Female sex 263 (38.7) 114 (39.2) 0.884 0.01 91 (40.4) 91 (40.4) 1.000 0
BMI, kg/m2 25.0 ± 4.5 25.4 ± 4.8 0.258 0.019 25.4 ± 4.9 25.0 ± 4.7 0.400 0.017
eGFR, ml/min/1.73 m2 61 ± 21 66 ± 26 0.003 0.009 64 ± 23 64 ± 26 0.878 0.001
Dialysis 14 (2.1) 7 (2.4) 0.734 0.02 3 (1.3) 6 (2.7) 0.503 0.1
Haematocrit, % 38 ± 6 37 ± 5 0.047 0.026 36 ± 6 37 ± 5 0.206 0.019
Haemoglobin, g/dl 12.4 ± 2.0 12.1 ± 1.9 0.002 0.075 11.8 ± 2.0 12.1 ± 1.9 0.128 0.085
Platelets, 109/L 210 ± 83 213 ± 79 0.552 0 216 ± 88 209 ± 74 0.418 0
Aspirin 279 (39.9) 69 (23.7) <0.0001 0.353 60 (26.7) 60 (26.7) 1.000 0
Clopidogrel 64 (9.4) 28 (9.6) 0.918 0.007 22 (9.8) 22 (9.8) 1.000 0
Warfarin 94 (13.8) 24 (8.2) 0.015 0.18 24 (10.7) 21 (9.3) 0.637 0.047
NYHA class III-IV 94 (13.8) 74 (25.4) <0.0001 0.295 42 (18.7) 44 (19.6) 0.810 0.023
Atrial fibrillation 145 (21.3) 62 (21.3) 0.995 0 49 (21.8) 50 (22.2) 0.909 0.01
Hypertension 379 (55.7) 194 (66.7) 0.002 0.227 143 (53.6) 142 (63.1) 0.922 0.194
Diabetes 152 (22.4) 42 (14.4) 0.005 0.208 37 (16.4) 36 (16.0) 0.898 0.011
Pulmonary disease 86 (12.6) 40 (13.7) 0.641 0.033 34 (15.1) 28 (12.4) 0.412 0.078
Dyslipidaemia 200 (29.4) 123 (42.3) <0.0001 0.271 85 (37.8) 83 (36.9) 0.845 0.019
Peripheral vascular disease 110 (16.2) 59 (20.3) 0.123 0.106 38 (16.9) 38 (16.9) 1.000 0
Cerebrovascular disease 63 (9.3) 48 (16.5) 0.001 0.216 26 (11.6) 30 (13.3) 0.568 0.052
Prior cardiac surgery 91 (13.4) 46 (15.8) 0.320 0.068 37 (16.4) 34 (15.1) 0.698 0.036
Myocardial infarction 185 (27.2) 48 (16.5) <0.0001 0.261 43 (19.1) 41 (18.2) 0.809 0.023
LVEF, % 52 ± 13 53 ± 11 0.106 0.01 53 ± 12 52 ± 11 0.796 0.002
Emergency 161 (23.7) 49 (16.8) 0.018 0.172 45 (20.0) 41 (18.2) 0.632 0.046
Pre-operative IABP 36 (5.3) 14 (4.8) 0.755 0.023 14 (6.2) 9 (4.0) 0.284 0.1
  1. BMI body mass index, eGFR estimated glomerular filtration rate, IABP intra-aortic balloon pump, LVEF left ventricular ejection fraction, NYHA New York Heart Association, PCC prothrombin complex concentrates, SD standard deviation
  2. Continuous variables are reported as mean and standard deviation; nominal variables are reported as counts (percentages)