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Table 1 Baseline characteristics of patients with reference to PCC administration

From: Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery

 

Overall series

Propensity score–matched pairs

 

No PCC (n = 680)

PCC (n = 291)

p Value

Pre-match SD

No PCC (n = 225)

PCC (n = 225)

p Value

Post-match SD

Age, yr

69.8 ± 10.1

69.0 ± 12.3

0.963

0.006

69.7 ± 10.6

69.2 ± 11.6

0.932

0.004

Female sex

263 (38.7)

114 (39.2)

0.884

0.01

91 (40.4)

91 (40.4)

1.000

0

BMI, kg/m2

25.0 ± 4.5

25.4 ± 4.8

0.258

0.019

25.4 ± 4.9

25.0 ± 4.7

0.400

0.017

eGFR, ml/min/1.73 m2

61 ± 21

66 ± 26

0.003

0.009

64 ± 23

64 ± 26

0.878

0.001

Dialysis

14 (2.1)

7 (2.4)

0.734

0.02

3 (1.3)

6 (2.7)

0.503

0.1

Haematocrit, %

38 ± 6

37 ± 5

0.047

0.026

36 ± 6

37 ± 5

0.206

0.019

Haemoglobin, g/dl

12.4 ± 2.0

12.1 ± 1.9

0.002

0.075

11.8 ± 2.0

12.1 ± 1.9

0.128

0.085

Platelets, 109/L

210 ± 83

213 ± 79

0.552

0

216 ± 88

209 ± 74

0.418

0

Aspirin

279 (39.9)

69 (23.7)

<0.0001

0.353

60 (26.7)

60 (26.7)

1.000

0

Clopidogrel

64 (9.4)

28 (9.6)

0.918

0.007

22 (9.8)

22 (9.8)

1.000

0

Warfarin

94 (13.8)

24 (8.2)

0.015

0.18

24 (10.7)

21 (9.3)

0.637

0.047

NYHA class III-IV

94 (13.8)

74 (25.4)

<0.0001

0.295

42 (18.7)

44 (19.6)

0.810

0.023

Atrial fibrillation

145 (21.3)

62 (21.3)

0.995

0

49 (21.8)

50 (22.2)

0.909

0.01

Hypertension

379 (55.7)

194 (66.7)

0.002

0.227

143 (53.6)

142 (63.1)

0.922

0.194

Diabetes

152 (22.4)

42 (14.4)

0.005

0.208

37 (16.4)

36 (16.0)

0.898

0.011

Pulmonary disease

86 (12.6)

40 (13.7)

0.641

0.033

34 (15.1)

28 (12.4)

0.412

0.078

Dyslipidaemia

200 (29.4)

123 (42.3)

<0.0001

0.271

85 (37.8)

83 (36.9)

0.845

0.019

Peripheral vascular disease

110 (16.2)

59 (20.3)

0.123

0.106

38 (16.9)

38 (16.9)

1.000

0

Cerebrovascular disease

63 (9.3)

48 (16.5)

0.001

0.216

26 (11.6)

30 (13.3)

0.568

0.052

Prior cardiac surgery

91 (13.4)

46 (15.8)

0.320

0.068

37 (16.4)

34 (15.1)

0.698

0.036

Myocardial infarction

185 (27.2)

48 (16.5)

<0.0001

0.261

43 (19.1)

41 (18.2)

0.809

0.023

LVEF, %

52 ± 13

53 ± 11

0.106

0.01

53 ± 12

52 ± 11

0.796

0.002

Emergency

161 (23.7)

49 (16.8)

0.018

0.172

45 (20.0)

41 (18.2)

0.632

0.046

Pre-operative IABP

36 (5.3)

14 (4.8)

0.755

0.023

14 (6.2)

9 (4.0)

0.284

0.1

  1. BMI body mass index, eGFR estimated glomerular filtration rate, IABP intra-aortic balloon pump, LVEF left ventricular ejection fraction, NYHA New York Heart Association, PCC prothrombin complex concentrates, SD standard deviation
  2. Continuous variables are reported as mean and standard deviation; nominal variables are reported as counts (percentages)