Parameter | Per muscle wet weight (pmol/s.mg Ww) | Per CS activity (pmol.nkat-1.s-1) | |||||
---|---|---|---|---|---|---|---|
ICU (n = 7) | Control (n = 8) | P | ICU (n = 7) | Control (n = 8) | P | ||
OXPHOS (3p) | 7.6 (5.0–8.8)* | 13.9 (11.3–17.9) | <0.01 | 31 (28–36)* | 37 (32–74) | 0.15 | |
RC capacity (3u) | 8.6 (6.7–10.5) | 16.4 (13.0–20.6) | 0.03 | 41 (37–44) | 42 (37–98) | 0.46 | |
Non-mito OCR | 0.8 (0.6–1.5) | 0.8 (0.6–1.3) | 0.91 | 4 (3–5) | 2 (1–4) | 0.16 | |
F1FoATPase | Absolute | 6.1 (4.8–7.6)* | 12.6 (9.2–13.0) | <0.01 | 26 (26–30)* | 33 (29–49) | 0.46 |
% OXPHOS | 81 (77–83)* | 84 (80–89) | 0.36 | 81 (77–83)* | 84 (80–89) | 0.36 | |
Proton leak | Absolute | 1.3 (1.0–1.4)* | 2.2 (1.3–3.6) | 0.10 | 8 (5–9)* | 7 (4–11) | 0.95 |
% OXPHOS | 19 (17–23)* | 16 (11–20) | 0.36 | 19 (17–23)* | 16 (11–20) | 0.36 | |
Complex I | 4.8 (4.0–6.1) | 6.7 (5.5–8.6) | 0.19 | 23 (22–35) | 23 (18–26) | 0.35 | |
Complex II | 4.6 (2.9–6,5) | 1.5 (0.8–3.8) | 0.06 | 23 (20–28) | 8 (3–14) | <0.01 | |
Complex III/ GPDH | 1.5 (1.1–1.9) | 0.8 (0.4–1.3) | 0.12 | 7.4 (6.0–9.3) | 1.8 (1.2–3.9) | <0.01 | |
Complex IV | 15.5 (13.0–19.5) | 19.7 (15.3–27.5) | 0.30 | 88 (69–99) | 49 (40–113) | 0.12 |