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Table 2 Liver laboratory parameters, cytokines and kidney retention parameters before and after ECAD

From: Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure – a prospective, randomised crossover study

 

MARS, median (IQR)

SPAD, median (IQR)

 

Before

After

Difference

Before

After

Difference

Bilirubin, μmol/L

323 (255.5–372.0)

249 (192.0–286.5)

*

315 (249.5–389.5)

243 (199.5–309.5)

*

GGT, μmol/L

1.69 (0.805–4.567)

1.52 (0.760–4.125)

*

1.66 (0.760–3.960)

1.53 (0.795–4.020)

**

TBA, μmol/L

119 (51.6–245.1)

75 (30.9–167.0)

*

105 (58.1–218.9)

97 (50.7–202.4)

**

ABiC, %

67 (55.2–80.6)

76 (67.5–90.4)

*

66 (57.4–77.8)

71 (60.3–81.1)

**

IL-6, pg/ml

142 (62.4–358.9)

123 (63.0–268.8)

n.s.

185 (94.3–369.8)

173 (55.9–385.8)

n.s.

IL-8, pg/ml

66 (46.2–100.9)

65 (49.7–94.9)

n.s.

70 (46.6–124.5)

68 (45.6–108.1)

n.s.

Creatinine, μmol/L

132 (85.5–186.5)

101 (64.0–145.9)

*

139 (79.0–201.5)

146 (83.0–199.8)

**

Urea, mmol/L

11.6 (7.13–17.10)

10.5 (6.60–15.30)

*

12.8 (8.35–18.10)

13.4 (8.93–16.88)

**

  1. ECAD extracorporeal albumin dialysis, MARS Molecular Adsorbents Recirculating System, SPAD single-pass albumin dialysis, GGT γ-glutamyl transferase, TBA total bile acid, ABiC albumin-binding capacity, IQR interquartile range, IL interleukin, n.s. non-significant
  2. *p < 0.05 significant changes within ECAD
  3. **p < 0.05 significant differences between both devices