Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

Table 5 Linear regression parameters for predicting PK parameters using drug properties

Group	Dependent	Independent	Mean	Lower	Upper	p Value
HS	CL	logP	−0.54	−2.37	1.29	0.556
E24H	CL	logP	−0.12	−0.86	0.62	0.744
SE24H	CL	logP	−0.41	−1.09	0.28	0.235
HS	CL	PB	−0.13	−0.22	−0.03	0.01
E24H	CL	PB	−0.08	−0.11	−0.04	<0.001
SE24H	CL	PB	−0.07	−0.10	−0.04	<0.001
HS	V_ss	logP	−0.48	−8.43	7.46	0.903
E24H	V_ss	logP	2.85	1.73	3.97	<0.001
SE24H	V_ss	logP	3.84	2.18	5.50	<0.001
HS	V_ss	PB	−0.50	−0.92	−0.09	0.017
E24H	V_ss	PB	−0.10	−0.17	−0.04	0.004
SE24H	V_ss	PB	−0.10	−0.21	0.00	0.056

PB protein binding, logP octanol-water partition coefficient (measure of drug lipophilicity)
Separate results for each group are presented for healthy sheep (HS, n = 7), healthy sheep on extracorporeal membrane oxygenation (E24H, n = 7), sheep with smoke inhalation acute lung injury on extracorporeal membrane oxygenation (SE24H, n = 6) and pharmacokinetic (PK) parameters clearance (CL) and steady-state volume of distribution (V_ss)

ISSN: 1364-8535