|
Study drug
|
Group
|
Cmax (mg/L)
|
Cmin (mg/L)
|
AUC0–∞ (mg/h/L)
|
Vss (L)
|
Clearance (L/h)
|
MRT (h)
|
|---|
|
Ceftriaxone
|
HS
|
71 (14)
|
0.0 (0.1)
|
202 (46)
|
9.0 (1.8)
|
2.6 (0.6)
|
3.5 (0.2)
|
|
E24H
|
86 (15)
|
1.2 (1.4)
|
135 (74)a
|
6.3 (1.4)a
|
4.3 (1.4)a
|
1.7 (0.8)a
|
|
SE24H
|
85 (18)
|
1.0 (0.3)b,c
|
142 (39)
|
7.4 (1.8)
|
3.6 (0.8)
|
2.1 (0.6)b
|
|
Vancomycin
|
HS
|
48 (9)
|
0.0 (0)
|
180 (37)
|
12.4 (2.6)
|
2.8 (0.7)
|
4.5 (0.2)
|
|
E24H
|
52 (10)
|
1.59 (0.9)a
|
131 (60)a
|
15.7 (3.9)
|
4.0 (1.1)a
|
4.0 (0.6)
|
|
SE24H
|
51 (12)
|
2.2 (0.4)b
|
116 (20)b
|
19.3 (3.3)b
|
3.9 (0.6)b
|
4.9 (0.7)c
|
|
Gentamicin
|
HS
|
20 (2)
|
0.0 (0)
|
78 (7)
|
13.0 (1.3)
|
3.1 (0.3)
|
4.3 (0.1)
|
|
E24H
|
12 (6)a
|
0.3 (0.3)a
|
25 (12)a
|
34 (23.5)a
|
12.1 (7.4)a
|
2.7 (0.5)a
|
|
SE24H
|
16 (2)b
|
0.6 (0.2)b,c
|
39 (6.5)b
|
20.1 (2.9)b
|
5.9 (1.0)b,c
|
3.5 (0.7)b,c
|
|
Meropenem
|
HS
|
26 (16)
|
0.0 (0.1)
|
71 (45)
|
91.0 (138)
|
20.9 (28)
|
3.9 (0.8)
|
|
E24H
|
27 (13)
|
0.5 (0.4)
|
36 (26)
|
16.5 (3.0)
|
13.8 (4.9)
|
1.4 (0.9)a
|
|
SE24H
|
29 (7)
|
0.3 (0.1)
|
39 (9.0)
|
19.9 (3.7)
|
13.2 (2.4)
|
1.6 (0.3)b
|
|
Doripenem
|
HS
|
26 (17)
|
0 (0)
|
73 (47)
|
63.8 (83)
|
17.6 (22)
|
3.5 (0.2)
|
|
E24H
|
30 (6)
|
0 (0)
|
42 (20)
|
17.1 (2.8)
|
13.5 (4.6)
|
1.5 (0.9)a
|
|
SE24H
|
28 (6)
|
0 (0)
|
39 (8)
|
20.2 (3.0)
|
13.1 (2.4)
|
1.6 (0.2)b
|
|
Ciprofloxacin
|
HS
|
3.3 (0.5)
|
0 (0)
|
13.6 (1.8)
|
31.9 (4.4)
|
7.2 (0.9)
|
4.5 (0.3)
|
|
E24H
|
5.1 (1.1)a
|
0.1 (0.1)a
|
8.3 (1.5)a
|
39.0 (7.6)a
|
11.8 (2.5)a
|
3.5 (1.2)a
|
|
SE24H
|
5.8 (1.2)b
|
0.1 (0.1)b,c
|
10.2 (1.5)b,c
|
52.7 (9.1)b,c
|
8.2 (1.2)c
|
6.4 (0.5)b,c
|
|
Fluconazole
|
HS
|
7.7 (0.9)
|
0 (0)
|
48.2 (6.2)
|
13.3 (2.2)
|
1.2 (0.3)
|
12.0 (5.8)
|
|
E24H
|
9.1 (1.2)a
|
2.6 (0.8)d
|
51.0 (5.0)
|
16.7 (2.8)a
|
1.0 (0.3)
|
17.1 (5.5)
|
|
SE24H
|
9.2 (1.4)b
|
2.9 (0.5)b
|
52.3 (3.5)
|
17.7 (3.4)b
|
0.8 (0.5)b
|
33.7 (29)b
|
|
Caspofungin
|
HS
|
5.7 (1.0)
|
0 (0)
|
33.8 (7.3)
|
10.0 (2.5)
|
0.8 (0.1)
|
12.9 (2.6)
|
|
E24H
|
4.8 (0.8)
|
0.7 (0.2)a
|
22.3 (6.6)a
|
14.4 (5.0)a
|
1.9 (0.4)a
|
7.6 (1.9)a
|
|
SE24H
|
4.3 (1.3)b
|
0.4 (0.2)b,c
|
15.5 (3.7)b,c
|
18.8 (8.4)b
|
2.8 (0.9)b,c
|
7.9 (6.4)b
|
- HS healthy sheep (n = 7), E24H healthy sheep on extracorporeal membrane oxygenation (n = 7), SE24H sheep with smoke inhalation acute lung injury on extracorporeal membrane oxygenation (n = 6), AUC area under the curve, MRT mean resident time, Vss steady-state volume of distribution, Cmax maximum plasma concentration, Cmin minimum plasma concentration
- aStatistically significant results for E24H group compared with HS group
- bStatistically significant results for SE24H group compared with HS group
- cStatistically significant differences between E24H and SE24H groups
