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Table 4 Non-compartmental pharmacokinetic estimates for eight study drugs for all three study groups

From: Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

Study drug Group Cmax (mg/L) Cmin (mg/L) AUC0–∞ (mg/h/L) Vss (L) Clearance (L/h) MRT (h)
Ceftriaxone HS 71 (14) 0.0 (0.1) 202 (46) 9.0 (1.8) 2.6 (0.6) 3.5 (0.2)
E24H 86 (15) 1.2 (1.4) 135 (74)a 6.3 (1.4)a 4.3 (1.4)a 1.7 (0.8)a
SE24H 85 (18) 1.0 (0.3)b,c 142 (39) 7.4 (1.8) 3.6 (0.8) 2.1 (0.6)b
Vancomycin HS 48 (9) 0.0 (0) 180 (37) 12.4 (2.6) 2.8 (0.7) 4.5 (0.2)
E24H 52 (10) 1.59 (0.9)a 131 (60)a 15.7 (3.9) 4.0 (1.1)a 4.0 (0.6)
SE24H 51 (12) 2.2 (0.4)b 116 (20)b 19.3 (3.3)b 3.9 (0.6)b 4.9 (0.7)c
Gentamicin HS 20 (2) 0.0 (0) 78 (7) 13.0 (1.3) 3.1 (0.3) 4.3 (0.1)
E24H 12 (6)a 0.3 (0.3)a 25 (12)a 34 (23.5)a 12.1 (7.4)a 2.7 (0.5)a
SE24H 16 (2)b 0.6 (0.2)b,c 39 (6.5)b 20.1 (2.9)b 5.9 (1.0)b,c 3.5 (0.7)b,c
Meropenem HS 26 (16) 0.0 (0.1) 71 (45) 91.0 (138) 20.9 (28) 3.9 (0.8)
E24H 27 (13) 0.5 (0.4) 36 (26) 16.5 (3.0) 13.8 (4.9) 1.4 (0.9)a
SE24H 29 (7) 0.3 (0.1) 39 (9.0) 19.9 (3.7) 13.2 (2.4) 1.6 (0.3)b
Doripenem HS 26 (17) 0 (0) 73 (47) 63.8 (83) 17.6 (22) 3.5 (0.2)
E24H 30 (6) 0 (0) 42 (20) 17.1 (2.8) 13.5 (4.6) 1.5 (0.9)a
SE24H 28 (6) 0 (0) 39 (8) 20.2 (3.0) 13.1 (2.4) 1.6 (0.2)b
Ciprofloxacin HS 3.3 (0.5) 0 (0) 13.6 (1.8) 31.9 (4.4) 7.2 (0.9) 4.5 (0.3)
E24H 5.1 (1.1)a 0.1 (0.1)a 8.3 (1.5)a 39.0 (7.6)a 11.8 (2.5)a 3.5 (1.2)a
SE24H 5.8 (1.2)b 0.1 (0.1)b,c 10.2 (1.5)b,c 52.7 (9.1)b,c 8.2 (1.2)c 6.4 (0.5)b,c
Fluconazole HS 7.7 (0.9) 0 (0) 48.2 (6.2) 13.3 (2.2) 1.2 (0.3) 12.0 (5.8)
E24H 9.1 (1.2)a 2.6 (0.8)d 51.0 (5.0) 16.7 (2.8)a 1.0 (0.3) 17.1 (5.5)
SE24H 9.2 (1.4)b 2.9 (0.5)b 52.3 (3.5) 17.7 (3.4)b 0.8 (0.5)b 33.7 (29)b
Caspofungin HS 5.7 (1.0) 0 (0) 33.8 (7.3) 10.0 (2.5) 0.8 (0.1) 12.9 (2.6)
E24H 4.8 (0.8) 0.7 (0.2)a 22.3 (6.6)a 14.4 (5.0)a 1.9 (0.4)a 7.6 (1.9)a
SE24H 4.3 (1.3)b 0.4 (0.2)b,c 15.5 (3.7)b,c 18.8 (8.4)b 2.8 (0.9)b,c 7.9 (6.4)b
  1. HS healthy sheep (n = 7), E24H healthy sheep on extracorporeal membrane oxygenation (n = 7), SE24H sheep with smoke inhalation acute lung injury on extracorporeal membrane oxygenation (n = 6), AUC area under the curve, MRT mean resident time, Vss steady-state volume of distribution, Cmax maximum plasma concentration, Cmin minimum plasma concentration
  2. aStatistically significant results for E24H group compared with HS group
  3. bStatistically significant results for SE24H group compared with HS group
  4. cStatistically significant differences between E24H and SE24H groups