|
Variable
|
Mean
|
Lower
|
Upper
|
p Value
|
|---|
|
Heart rate
|
1.41
|
−9.54
|
12.36
|
0.815
|
|
Mean arterial BP
|
−23.83
|
−31.35
|
−16.25
|
<0.001
|
|
Mean PAP
|
1.77
|
−0.83
|
4.37
|
0.234
|
|
CVP
|
0.93
|
−3.00
|
4.86
|
0.669
|
|
CCO
|
−2.09
|
−3.30
|
−0.87
|
0.01
|
|
SvO2
|
−0.78
|
−3.31
|
1.74
|
0.585
|
|
PEEP
|
2.09
|
0.66
|
3.52
|
0.02
|
|
Respiratory rate (sheep)
|
2.33
|
0.18
|
4.48
|
0.068
|
|
Tidal volume
|
−38.24
|
−135.38
|
58.87
|
0.479
|
|
FiO2
|
7.77
|
−2.04
|
17.69
|
0.151
|
|
paO2
|
48.05
|
0.43
|
95.67
|
0.053
|
|
paCO2
|
3.12
|
−0.28
|
6.52
|
0.115
|
|
Running fluid balance
|
4604.14
|
2779.38
|
6428.89
|
<0.001
|
|
ctHb
|
2.00
|
1.34
|
2.66
|
<0.001
|
|
pH
|
−0.07
|
−0.10
|
−0.03
|
0.003
|
|
Body temperature
|
−0.06
|
−0.38
|
0.27
|
0.754
|
|
Lactate
|
0.71
|
0.26
|
1.16
|
0.013
|
|
Midazolam dose per hour
|
−5.97
|
−21.37
|
9.42
|
0.485
|
|
Urine output
|
6.68
|
−54.88
|
68.25
|
0.843
|
|
Albumin
|
−14.91
|
−16.70
|
−13.10
|
<0.001
|
|
ALT
|
5.12
|
−6.25
|
16.49
|
0.419
|
|
AST
|
82.87
|
−23.66
|
189.39
|
0.175
|
|
Bilirubin (Direct)
|
−0.48
|
−1.68
|
0.73
|
0.476
|
|
Bilirubin (Total)
|
−0.12
|
−0.71
|
0.50
|
0.823
|
|
Creatinine
|
0.56
|
−11.52
|
12.64
|
0.933
|
|
Total protein
|
−26.60
| | |
<0.001
|
|
Urea
|
0.79
|
−0.47
|
2.06
|
0.271
|
|
Urine creatinine
|
−4327.47
|
−9508.52
|
974.49
|
0.322
|
- BP blood pressure, PAP pulmonary arterial pressure, CVP central venous pressure, CCO continuous cardiac output, SvO2 mixed venous oxygen saturation, PEEP positive end-expiratory pressure, FiO2 fraction of inspired oxygen, paO2 partial pressure of oxygen, paCO2 partial pressure of carbon dioxide, ctHb concentration of total blood haemoglobin, ALT alanine aminotransferase, AST aspartate aminotransferase
- The analysis was carried out using a mixed model with a random intercept for each sample. The results are presented as mean difference and 95 % confidence intervals, including a linear time trend and using each sheep’s baseline (time 0) as a covariate
