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Table 3 Mean differences in Physiologic parameters of E24H and SE24H groups during the pharmacokinetic sampling interval

From: Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

Variable Mean Lower Upper p Value
Heart rate 1.41 −9.54 12.36 0.815
Mean arterial BP −23.83 −31.35 −16.25 <0.001
Mean PAP 1.77 −0.83 4.37 0.234
CVP 0.93 −3.00 4.86 0.669
CCO −2.09 −3.30 −0.87 0.01
SvO2 −0.78 −3.31 1.74 0.585
PEEP 2.09 0.66 3.52 0.02
Respiratory rate (sheep) 2.33 0.18 4.48 0.068
Tidal volume −38.24 −135.38 58.87 0.479
FiO2 7.77 −2.04 17.69 0.151
paO2 48.05 0.43 95.67 0.053
paCO2 3.12 −0.28 6.52 0.115
Running fluid balance 4604.14 2779.38 6428.89 <0.001
ctHb 2.00 1.34 2.66 <0.001
pH −0.07 −0.10 −0.03 0.003
Body temperature −0.06 −0.38 0.27 0.754
Lactate 0.71 0.26 1.16 0.013
Midazolam dose per hour −5.97 −21.37 9.42 0.485
Urine output 6.68 −54.88 68.25 0.843
Albumin −14.91 −16.70 −13.10 <0.001
ALT 5.12 −6.25 16.49 0.419
AST 82.87 −23.66 189.39 0.175
Bilirubin (Direct) −0.48 −1.68 0.73 0.476
Bilirubin (Total) −0.12 −0.71 0.50 0.823
Creatinine 0.56 −11.52 12.64 0.933
Total protein −26.60    <0.001
Urea 0.79 −0.47 2.06 0.271
Urine creatinine −4327.47 −9508.52 974.49 0.322
  1. BP blood pressure, PAP pulmonary arterial pressure, CVP central venous pressure, CCO continuous cardiac output, SvO2 mixed venous oxygen saturation, PEEP positive end-expiratory pressure, FiO2 fraction of inspired oxygen, paO2 partial pressure of oxygen, paCO2 partial pressure of carbon dioxide, ctHb concentration of total blood haemoglobin, ALT alanine aminotransferase, AST aspartate aminotransferase
  2. The analysis was carried out using a mixed model with a random intercept for each sample. The results are presented as mean difference and 95 % confidence intervals, including a linear time trend and using each sheep’s baseline (time 0) as a covariate