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Table 2 Demographic and physiologic data at baseline after initiation of anaesthesia, mechanical ventilation and haemodynamic monitoring and before smoke inhalation and commencement of ECMO

From: Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

 

Group

Mean

SD

p Value

Weight, kg

E24H

48.5

4.6

0.84

 

SE24H

49.6

4.4

 

Heart rate, beats/min

E24H

116

13

0.78

 

SE24H

118

11

 

Mean arterial BP, mmHg

E24H

116.1

6.8

0.91

 

SE24H

115.7

8.1

 

Mean PAP, mmHg

E24H

24.6

2.8

0.06

 

SE24H

21.2

3.2

 

CVP, cmH2O

E24H

15.6

2.8

0.06

 

SE24H

12.2

3.2

 

CCO, L/min

E24H

5.44

0.93

0.33

 

SE24H

5.03

0.46

 

SvO2, %

E24H

78.8

7.1

0.31

 

SE24H

82.0

4.1

 

PEEP, cmH2O

E24H

8.1

2.6

0.67

 

SE24H

7.5

2.7

 

Respiratory rate, breaths/min

E24H

10.9

6.0

0.6

 

SE24H

12.5

5.2

 

Fluid balance, ml

E24H

681

376

0.11

 

SE24H

926

68

 

Haemoglobin, g/L

E24H

7.0

1.2

0.47

 

SE24H

7.6

1.7

 

pH

E24H

7.385

0.031

0.62

 

SE24H

7.397

0.052

 

Body temperature, °C

E24H

38.26

0.61

0.67

 

SE24H

38.13

0.50

 

Lactate, mmol/L

E24H

1.34

0.44

0.17

 

SE24H

1.07

0.24

 

Midazolam dose, mg/h

E24H

14.4

1.2

0.17

 

SE24H

15.0

0.0

 

Urine output, ml/h

E24H

69

44

0.87

 

SE24H

74

68

 

Albumin, g/L

E24H

37.16

2.53

0.33

 

SE24H

38.15

0.86

 

Alanine aminotransferase (U/L)

E24H

11.7

2.1

0.51

 

SE24H

12.4

1.7

 

Serum bilirubin, μmol/L

E24H

2.16

0.69

0.75

 

SE24H

2.03

0.74

 

Serum creatinine, μmol/L

E24H

88

15

0.94

 

SE24H

87

11

 

Total protein, g/L

E24H

71.7

6.4

0.78

 

SE24H

71.0

1.9

 

Urine creatinine, μmol/L

E24H

10,172

3798

0.17

 

SE24H

15,541

8009

 
  1. BP blood pressure, PAP pulmonary arterial pressure, CVP central venous pressure, CCO continuous cardiac output, SvO2 mixed venous oxygen saturation, PEEP positive end-expiratory pressure
  2. Data presented are derived from comparison of the results between groups: healthy sheep on extracorporeal membrane oxygenation (E24H) (n = 7), sheep with smoke inhalation acute lung injury on extracorporeal membrane oxygenation (SE24H) (n = 6)