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Table 2 Demographic and physiologic data at baseline after initiation of anaesthesia, mechanical ventilation and haemodynamic monitoring and before smoke inhalation and commencement of ECMO

From: Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

  Group Mean SD p Value
Weight, kg E24H 48.5 4.6 0.84
  SE24H 49.6 4.4  
Heart rate, beats/min E24H 116 13 0.78
  SE24H 118 11  
Mean arterial BP, mmHg E24H 116.1 6.8 0.91
  SE24H 115.7 8.1  
Mean PAP, mmHg E24H 24.6 2.8 0.06
  SE24H 21.2 3.2  
CVP, cmH2O E24H 15.6 2.8 0.06
  SE24H 12.2 3.2  
CCO, L/min E24H 5.44 0.93 0.33
  SE24H 5.03 0.46  
SvO2, % E24H 78.8 7.1 0.31
  SE24H 82.0 4.1  
PEEP, cmH2O E24H 8.1 2.6 0.67
  SE24H 7.5 2.7  
Respiratory rate, breaths/min E24H 10.9 6.0 0.6
  SE24H 12.5 5.2  
Fluid balance, ml E24H 681 376 0.11
  SE24H 926 68  
Haemoglobin, g/L E24H 7.0 1.2 0.47
  SE24H 7.6 1.7  
pH E24H 7.385 0.031 0.62
  SE24H 7.397 0.052  
Body temperature, °C E24H 38.26 0.61 0.67
  SE24H 38.13 0.50  
Lactate, mmol/L E24H 1.34 0.44 0.17
  SE24H 1.07 0.24  
Midazolam dose, mg/h E24H 14.4 1.2 0.17
  SE24H 15.0 0.0  
Urine output, ml/h E24H 69 44 0.87
  SE24H 74 68  
Albumin, g/L E24H 37.16 2.53 0.33
  SE24H 38.15 0.86  
Alanine aminotransferase (U/L) E24H 11.7 2.1 0.51
  SE24H 12.4 1.7  
Serum bilirubin, μmol/L E24H 2.16 0.69 0.75
  SE24H 2.03 0.74  
Serum creatinine, μmol/L E24H 88 15 0.94
  SE24H 87 11  
Total protein, g/L E24H 71.7 6.4 0.78
  SE24H 71.0 1.9  
Urine creatinine, μmol/L E24H 10,172 3798 0.17
  SE24H 15,541 8009  
  1. BP blood pressure, PAP pulmonary arterial pressure, CVP central venous pressure, CCO continuous cardiac output, SvO2 mixed venous oxygen saturation, PEEP positive end-expiratory pressure
  2. Data presented are derived from comparison of the results between groups: healthy sheep on extracorporeal membrane oxygenation (E24H) (n = 7), sheep with smoke inhalation acute lung injury on extracorporeal membrane oxygenation (SE24H) (n = 6)