Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

Table 2 Demographic and physiologic data at baseline after initiation of anaesthesia, mechanical ventilation and haemodynamic monitoring and before smoke inhalation and commencement of ECMO

	Group	Mean	SD	p Value
Weight, kg	E24H	48.5	4.6	0.84
	SE24H	49.6	4.4
Heart rate, beats/min	E24H	116	13	0.78
	SE24H	118	11
Mean arterial BP, mmHg	E24H	116.1	6.8	0.91
	SE24H	115.7	8.1
Mean PAP, mmHg	E24H	24.6	2.8	0.06
	SE24H	21.2	3.2
CVP, cmH₂O	E24H	15.6	2.8	0.06
	SE24H	12.2	3.2
CCO, L/min	E24H	5.44	0.93	0.33
	SE24H	5.03	0.46
SvO₂, %	E24H	78.8	7.1	0.31
	SE24H	82.0	4.1
PEEP, cmH₂O	E24H	8.1	2.6	0.67
	SE24H	7.5	2.7
Respiratory rate, breaths/min	E24H	10.9	6.0	0.6
	SE24H	12.5	5.2
Fluid balance, ml	E24H	681	376	0.11
	SE24H	926	68
Haemoglobin, g/L	E24H	7.0	1.2	0.47
	SE24H	7.6	1.7
pH	E24H	7.385	0.031	0.62
	SE24H	7.397	0.052
Body temperature, °C	E24H	38.26	0.61	0.67
	SE24H	38.13	0.50
Lactate, mmol/L	E24H	1.34	0.44	0.17
	SE24H	1.07	0.24
Midazolam dose, mg/h	E24H	14.4	1.2	0.17
	SE24H	15.0	0.0
Urine output, ml/h	E24H	69	44	0.87
	SE24H	74	68
Albumin, g/L	E24H	37.16	2.53	0.33
	SE24H	38.15	0.86
Alanine aminotransferase (U/L)	E24H	11.7	2.1	0.51
	SE24H	12.4	1.7
Serum bilirubin, μmol/L	E24H	2.16	0.69	0.75
	SE24H	2.03	0.74
Serum creatinine, μmol/L	E24H	88	15	0.94
	SE24H	87	11
Total protein, g/L	E24H	71.7	6.4	0.78
	SE24H	71.0	1.9
Urine creatinine, μmol/L	E24H	10,172	3798	0.17
	SE24H	15,541	8009

BP blood pressure, PAP pulmonary arterial pressure, CVP central venous pressure, CCO continuous cardiac output, SvO₂ mixed venous oxygen saturation, PEEP positive end-expiratory pressure
Data presented are derived from comparison of the results between groups: healthy sheep on extracorporeal membrane oxygenation (E24H) (n = 7), sheep with smoke inhalation acute lung injury on extracorporeal membrane oxygenation (SE24H) (n = 6)

ISSN: 1364-8535