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Table 1 Lipophilicity and protein binding characteristics of study drugs

From: Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models

Study drug

Lipophilicity (logP)

Protein binding (%)

Ceftriaxone

−1.7

95

Ciprofloxacin

2.3

20–40

Caspofungin

0.1

97

Fluconazole

0.4

11–12

Gentamicin

−3.1

0–30

Meropenem

−0.6

2

Doripenem

0.7

8

Vancomycin

−3.1

55

  1. A higher numeric value for octanol-water partition coefficient (logP) indicates greater lipophilicity [29]