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Table 4 Neutrophil, lymphocyte, and NLCR variations from admission to day 5 in late survivors and late nonsurvivors

From: Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock

  Survivors after day 5 (n = 49) Late death after day 5 (n = 21) p Value
Age, yr 72.5 (61.6–79.3) 77.9 (64.4–85.7) 0.2
Female 16 (32.7) 9 (42.9) 0.41
Male 33 (67.3) 12 (57.1)  
Comorbidities
 CAD 12 (24.5) 3 (14.3) 0.34
 Diabetes 11 (22.4) 7 (33.3) 0.34
 COPD 7 (14.3) 2 (9.5) 0.59
 Cancer/immunosuppression 10 (20.4) 6 (28.6) 0.46
 Charlson comorbidity index score 5 (3–6) 5 (4–7) 0.66
Severity and outcome
 SAPS II 48 (42–56) 55 (49–61) 0.083
 SOFA score at admission 9 (6–10) 8 (6–9) 0.58
 In-ICU LOS 10 (7–18) 14 (10–22) 0.15
 Hospital-acquired infection 12 (24.5) 14 (66.7) 0.00082
Cell counts at admission
 Neutrophils, 109/L 8.2 (5.5–16.1) 10.9 (6.1–13.2) 0.68
 Lymphocytes, 109/L 0.7 (0.5–1.1) 1.2 (0.9–2) 0.0012
 NLCR 11.8 (6.6–18.3) 7 (4–12.9) 0.06
Cell counts at day 5
 Neutrophils, 109/L 9.2 (6.7–11.8) 16.4 (13.3–24.2) 0.0001
 Lymphocytes, 109/L 1 (0.8–1.3) 1 (0.7–1.3) 0.89
 NLCR 9.1 (6.7–12.5) 12.8 (8.4–35.4) 0.028
Cell counts variations from day 1 to day 5
 Neutrophils, % 6.3 (−47.2 to 75.3) 50.5 (3.4 to 207.0) 0.026
 Lymphocytes, % 33.3 (−20.0 to 141.7) −21.8 (−43.2 to 44.6) 0.034
 NLCR, % −20.0 (−57.4 to 45.9) 34.8 (−8.2 to 305.4) 0.003
  1. Abbreviations: CAD coronary artery disease, COPD chronic obstructive pulmonary disease, SAPS II Simplified Acute Physiology Score II, SOFA Sequential Organ Failure Assessment, ICU intensive care unit, LOS length of stay, NLCR neutrophil-to-lymphocyte count ratio