Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation

Table 2 Macrocirculatory changes after hemorrhagic shock and fluid resuscitation in part I of the experiment

	T₀	T₁	T₂	ANOVA group effects	ANOVA time effects	ANOVA group-time interaction
	Baseline	Completion of shock	End of experiment	ANOVA group effects	ANOVA time effects	ANOVA group-time interaction
MAP (mmHg)				p <0.001	p <0.001	p <0.001
Sham	104 (101–109)	109 (101–112)^*	103 (80–107)
Control	115 (100–118)	61 (46–74)	56 (46–67)^**
NS	103 (96–112)	61 (57–69)^**	80 (76–85)
HTS	104 (97–112)	68 (60–75)^**	89 (70–102)^*
GEL	108 (100–120)	66 (54–85)^**	89 (82–93)^*
HES	96 (90–105)	59 (55–64)^**	85 (72–99)^*
HR (/min)				p = 0.394	p <0.001	p = 0.153
Sham	361 (357–379)	375 (333–422)	355 (340–384)
Control	389 (356–400)	365 (342–379)	410 (358–416)
NS	346 (326–357)	341 (287–361)	346 (337–392)
HTS	365 (342–385)	348 (312–362)	400 (371–412)
GEL	379 (352–400)	340 (291–344)	370 (333–379)
HES	352 (346–376)	344 (323–384)	348 (332–382)

Data are median (interquartile range). *Value significantly higher than in the control group with p <0.05. **Value in fluid resuscitation or control group significantly different to sham group with p <0.05. ANOVA analysis of variance, T time, MAP mean arterial pressure, HR heart rate, NS 0.9 % saline, HTS hypertonic saline, HES hydroxyethyl starch, GEL gelatin

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