Fig. 3

Effect of treatment with C5 and CD14 inhibitors on complement activation in porcine polymicrobial sepsis. The plasma concentration of sC5b-9 was determined every 90 minutes during the 8-hour observation and additional samples were obtained from animals that died before the end of the observation period (panel a). The difference in mean increase from minimum to maximum values of complement activation between the treated and control groups are shown in (panel b). The sham animal data is included for reference. † = death before the end of the observation period. CAU = complement arbitrary units, see ref. [22]. C5 complement component 5, CD cluster of differentiation, sC5b-9 soluble terminal C5b-9 complement complex