Fig. 2

Effect of treatment with C5 and CD14 inhibitors on hemodynamics in porcine polymicrobial sepsis. Mean systemic arterial pressure (MAP) (panel a) and mean pulmonary artery pressures (MPAP) (panel b) for each subject were recorded every 5 minutes. The plots represent mean values with corresponding standard errors of means. The shaded area in panel b represents the difference in mean MPAP whereas the mean ratio of the MPAP to MAP is plotted in (panel c). Lines are drawn by simple linear regression. The sham animal curve is included for reference. C5 complement component 5, CD cluster of differentiation