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Table 1 Clinical characteristics and outcome of sepsis patients stratified according to survival status 30 days after admission

From: Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients

  All patients Survivors Non-survivors P
n = 1103 n = 786 n = 305
Demographics     
 Age, years, mean (SD) 61.2 (14.7) 59.7 (14.7) 64.9 (13.9) <0.0001
 Gender, male, n (%) 671 (60.8) 481 (61.2) 183 (60) 0.73
 Race, white, n (%) 972 (88.8) 689 (87.7) 273 (89.5) 0.45
 Body mass index, kg/m2, mean (SD) 26 (6.2) 26.2 (6.3) 25.5 (5.8) 0.09
 Admission type, medical, n (%) 817 (74.1) 562 (71.5) 247 (81) 0.001
 Charlson score, median (IQR) 4 (3–6) 4 (2–6) 5 (3–6) 0.0001
Site of infection     
 Pulmonary, n (%) 478 (43.3) 337 (37.1) 135 (44.3) 0.69
 Abdominal, n (%) 215 (19.5) 150 (19.1) 61 (20) 0.74
 Urinary, n (%) 109 (9.9) 84 (10.7) 24 (7.9) 0.69
 Other, n (%)a 173 (15.7) 123 (15.6) 49 (16.1) 0.93
 Coinfection, n (%) 128 (11.6) 92 (11.7) 36 (11.8) 1
Severity of disease in first 24 hours     
 APACHE IV score, median (IQR) 80 (63–101) 74 (59–92) 98 (81–122) <0.0001
 SOFA score, median (IQR)b 7 (5–9) 7 (4–9) 9 (6–12) <0.0001
 Shock, n (%) 373 (33.8) 234 (29.8) 135 (44.3) <0.001
 Mechanical ventilation, n (%) 851 (77.2) 590 (75.1) 249 (81.6) <0.05
 Renal replacement therapy, n (%) 115 (10.4) 60 (7.6) 53 (17.4) <0.001
Outcome     
 ICU length of stay, days, median (IQR) 4 (2–10) 5 (2–10) 3 (2–8) <0.01
 ICU mortality, n (%) 227 (20.6) 13 (1.7) 214 (70.2) <0.001
  1. 12 patients were lost to follow up.aSite of infection: “other” includes cardiovascular infection, mediastinitis and skin infection. bCentral nervous system not included in score. APACHE Acute Physiology and Chronic Health Evaluation, SOFA Sequential Organ Failure Assessment