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Table 4 Clinical outcomes of patients with viral pneumonia according to empiric antibacterial therapy

From: Impact of antibacterials on subsequent resistance and clinical outcomes in adult patients with viral pneumonia: an opportunity for stewardship

 

Long course

Short course

Mixed infection

(n = 67)

(n = 28)

(n = 79)

Instances of subsequent MDRO infection or colonization

25/47 (53.2)

4/19 (21.1)*

20/53 (37.7)

 MRSA colonization

2/10 (20)

0/7 (0)

3/15 (20)

 VRE colonization

3/6 (50)

1/4 (25)

9/20 (45)

 MDRO infection

20/31 (64.5)

3/8 (37.5)

8/18 (44.4)

Patients with subsequent MDRO infection or colonization

16 (23.9)

3 (10.7)

16 (20.3)

 MRSA colonization

2 (3.0)

0 (0)

3 (3.8)

 VRE colonization

3 (4.5)

1 (3.6)

9 (11.4)

 MDRO infection

13 (19.4)

3 (10.7)

7 (8.9)

Subsequent Clostridium difficile infection

1 (1.5)

0 (0)

2 (2.5)

In-hospital mortality

8 (11.9)

3 (10.7)

23 (29.1)**

 Non-ICU

1/23 (4.3)

0/11 (0)

0/16 (0)

 ICU (all)

7/44 (15.9)

3/17 (17.6)

23/63 (36.5)**

 ICU – oncology

4/18 (22.2)

2/5 (40)

10/16 (62.5)**

 ICU – nononcology

3/26 (11.5)

1/12 (8.3)

13/47 (27.7)

Hospital LOS (days)

11 (7–25)

8.5 (5–20)

17 (8.5-28) ***

ICU LOS (days)

8.1 (4.9-17.9)

4.2 (2.8-14.7)*

12 (5.1-19.1) ***

Readmit within

 30 days

14 (20.9)

4 (12.9)

19 (24.0)

 90 days

22 (32.8)

8 (25.8)

27 (48.2)

 180 days

30 (44.8)

11 (35.5)

29 (51.8)

  1. Data expressed as number (% of total) or median (interquartile range)
  2. LOS length of stay, MDRO multidrug-resistant organism, MRSA methicillin-resistant Staphylococcus aureus, VRE vancomycin-resistant enterococci
  3. *Statistically significant difference (P <0.05) between short-course and long-course groups
  4. **Statistically significant difference (P <0.05) between long-course and mixed-infection groups
  5. ***Statistically significant difference (P <0.05) between short-course and mixed-infection groups