Table 3 Patients having experienced a thrombotic and/or hemorrhagic episode

Thrombotic risk factor

Thrombosis at baseline

aPTT at baseline (sec)

Event during argatroban therapy

aPTT at diagnosis of the event (sec)

Dose of argatroban at diagnosis of thrombosis μg/kg/min

Anti-IIa^b (TT) at diagnosis of thrombosis (μg/ml)

Mean anti IIa^b (TT) (before diagnosis of thrombosis) (μg/ml)

 Patient 4

Obesity, lupus anticoagulant

DVT + PE

51.9

D7: DVT extension; D16: DVT extension (iliac vein) + blue toe syndrome; D29: PE recurrence

Mean aPTT ± SD

1.7

0.64

0.43 ± 0.12

91.3 ± 6.3

 Patient 8^a

Cancer; sepsis

PE

37.1

D4: new DTV (femoral vein); D16:thrombosis of the femoral and left external iliac vein + right jugular vein

49.5

10.5 (for 1 hour)

0.13

1.95 ± 2.82

 Patient 9

AF; cardiac insufficiency

Peripheral ischemia

36.8

D6: ischemia of the right lower limb

61.6

1.75

1.06

0.87 ± 0.35

 Patient 15

Sepsis

Cerebral ischemic lesions

39.9

D14: right internal jugular thrombosis

54.9

1.19

0.47

0.61 ± 0.12

 Patient 17

Obesity; AF; sepsis

Peripheral ischemia

48.7

D3: obstruction of the right femoral artery

135.8

0.8

1.44

1.51 ± 0.31

aPTT at baseline (sec)

Event during argatroban therapy

aPTT at diagnosis of the event (sec)

Dose of argatroban before bleeding μg/kg/min

Anti-IIa^b (TT) before bleeding (μg/ml)

Mean anti-IIa^b (TT) before bleeding (μg/ml)

 Patient 3

54.7

Major bleeding at D21: hematuria

63.9

0.62

0.61

0.43 ± 0.13

 Patient 8

37.1

Minor bleeding after 2-hour infusion: gums and nose

149.7

Medication error

6.15

n.a.

 Patient 14

63.9

Minor bleeding at D6: hematemesis; major bleeding at D9: rectorrhagia

66.6

0.12

0.66

0.67 ± 0.29

 Patient 17

48.7

Major bleeding at D5: puncture of a dialysis catheter

133

0.32

1.53

1.52 ± 0.22