Skip to main content

Table 4 Variables related to glycemic control

From: Diabetes-specific enteral nutrition formula in hyperglycemic, mechanically ventilated, critically ill patients: a prospective, open-label, blind-randomized, multicenter study

 

GROUP A

GROUP B

GROUP C

p value

(n = 52)

(n = 53)

(n = 52)

Administered insulin (IU/day)

19.1 (13.1)

23.7 (40.1)*a

20.3 (30.1)

<0.05*

Plasma glucose level (mg/dL)

138.6 (39.1)

146.1 (49.9)*a

143.9 (45.9)

<0.01*

Capillary glucose level (mg/dL)

146.1 (45.8)

155.3 (63.6)*a

150.1 (41.9)*b,c

<0.001*a

<0.01*b,c

Mean capillary glycemia on ICU day 1 (mg/dL)

147.5 (40.2)

160 (55.5)*d

145.6 (46.6)

<0.01*

Peak glucose level (mg/dL)

181.3 (52)

193.6 (74.6)

191.3 (65.8)

0.68

Number of capillary glycemia measurements

3605

3523

3557

0.57

Number of measurements per patient/day

5.7 (3.4)

5.81 (3.2)

5.46 (2.9)

0.56

Percentage of controls on 80–150 mg/dL

59 %

57.6 %

59.59 %

0.82

Hypoglycemia (50–80 mg/dL)

53 (1.48 %)

127 (3.63 %)*d

44 (1.25 %)

<0.05*

Hypoglycemia (<50 mg/dL)

-

4 (0.11 %)

1 (0.02 %)

0.32

Capillary glucose SD

45.83

63.67*d

41.98

<0.01*

Glycemic lability index (ICU days 1–28)

0.58 (0.2–1.4)

0.71 (0.3–1.9)*d

0.44 (0.2–1.2)

<0.05*

Glycemic lability index (ICU days 1–7)

0.27 (0.1–0.7)

0.6 (0.2–1.2)*d

0.27 (0.2–0.8)

<0.05*

Glycemic variability SD (mg/dL) (ICU days 1–28)

33.6 (18.4)

49.1 (21.5)*a

41.1 (9.3)

<0.01*

Glycemic variability SD (mg/dL) (ICU days 1–7)

43.2 (4.9)

68.5 (13.5)*d

42.5 (2.7)

<0.01*

Glycemic CV (%) (ICU days 1–28)

27.9 (5.8)

32.4 (11.2)

27.8 (5.2)

0.13

Glycemic CV (%) (ICU days 1–7)

28.3 (1.9)

42.6 (8.2)*d

28.4 (2.1)

<0.001*

  1. Values are provided as mean (SD) and percentages (%). Asterisks indicate statistical significance
  2. IU, international units, ICU intensive care unit, SD, standard deviation, CV coefficient of variation
  3. aDifference group A vs. group B
  4. bDifference group B vs. group C
  5. cDifference group A vs. group C
  6. dDifference group B vs. groups A and C