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Table 4 Variables related to glycemic control

From: Diabetes-specific enteral nutrition formula in hyperglycemic, mechanically ventilated, critically ill patients: a prospective, open-label, blind-randomized, multicenter study

  GROUP A GROUP B GROUP C p value
(n = 52) (n = 53) (n = 52)
Administered insulin (IU/day) 19.1 (13.1) 23.7 (40.1)*a 20.3 (30.1) <0.05*
Plasma glucose level (mg/dL) 138.6 (39.1) 146.1 (49.9)*a 143.9 (45.9) <0.01*
Capillary glucose level (mg/dL) 146.1 (45.8) 155.3 (63.6)*a 150.1 (41.9)*b,c <0.001*a
<0.01*b,c
Mean capillary glycemia on ICU day 1 (mg/dL) 147.5 (40.2) 160 (55.5)*d 145.6 (46.6) <0.01*
Peak glucose level (mg/dL) 181.3 (52) 193.6 (74.6) 191.3 (65.8) 0.68
Number of capillary glycemia measurements 3605 3523 3557 0.57
Number of measurements per patient/day 5.7 (3.4) 5.81 (3.2) 5.46 (2.9) 0.56
Percentage of controls on 80–150 mg/dL 59 % 57.6 % 59.59 % 0.82
Hypoglycemia (50–80 mg/dL) 53 (1.48 %) 127 (3.63 %)*d 44 (1.25 %) <0.05*
Hypoglycemia (<50 mg/dL) - 4 (0.11 %) 1 (0.02 %) 0.32
Capillary glucose SD 45.83 63.67*d 41.98 <0.01*
Glycemic lability index (ICU days 1–28) 0.58 (0.2–1.4) 0.71 (0.3–1.9)*d 0.44 (0.2–1.2) <0.05*
Glycemic lability index (ICU days 1–7) 0.27 (0.1–0.7) 0.6 (0.2–1.2)*d 0.27 (0.2–0.8) <0.05*
Glycemic variability SD (mg/dL) (ICU days 1–28) 33.6 (18.4) 49.1 (21.5)*a 41.1 (9.3) <0.01*
Glycemic variability SD (mg/dL) (ICU days 1–7) 43.2 (4.9) 68.5 (13.5)*d 42.5 (2.7) <0.01*
Glycemic CV (%) (ICU days 1–28) 27.9 (5.8) 32.4 (11.2) 27.8 (5.2) 0.13
Glycemic CV (%) (ICU days 1–7) 28.3 (1.9) 42.6 (8.2)*d 28.4 (2.1) <0.001*
  1. Values are provided as mean (SD) and percentages (%). Asterisks indicate statistical significance
  2. IU, international units, ICU intensive care unit, SD, standard deviation, CV coefficient of variation
  3. aDifference group A vs. group B
  4. bDifference group B vs. group C
  5. cDifference group A vs. group C
  6. dDifference group B vs. groups A and C