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Table 3 Prevalence of extracorporeal therapy use and mortality by age, co-morbidity, and organ dysfunction

From: Extracorporeal therapies in pediatric severe sepsis: findings from the pediatric health-care information system

Characteristic ECMO alone (N = 1358) RRT alone (N = 2937) ECMO + RRT (N = 500)
Prevalence Mortality Prevalence Mortality Prevalence Mortality
Age
 <1 year 661 (48.7 %) 344 (52.0 %) 368 (12.5 %) 144 (39.1 %) 169 (33.8 %) 111 (65.7 %)
 1-4 years 319 (23.5 %) 130 (40.8 %) 681 (23.2 %) 197 (28.9 %) 102 (20.4 %) 61 (59.8 %)
 5-9 years 126 (9.3 %) 57 (45.2 %) 465 (15.8 %) 133 (28.6 %) 66 (13.2 %) 27 (40.9 %)
 10-18 years 252 (18.6 %) 118 (46.8 %) 1423 (48.5 %) 474 (33.3 %) 163 (32.6 %) 91 (55.8 %)
Co-morbidity
 Any condition 1100 (81.0 %) 522 (47.5 %) 2289 (77.9 %) 806 (35.2 %) 356 (71.2 %) 206 (71.0 %)
 Neurologic 156 (11.5 %) 57 (36.5 %) 382 (13.0 %) 113 (29.6 %) 42 (8.4 %) 21 (50.0 %)
 Cardiovascular 885 (65.2 %) 404 (45.7 %) 615 (20.9 %) 261 (42.4 %) 234 (46.8 %) 135 (57.7 %)
 Respiratory 122 (9.0 %) 50 (41.0 %) 107 (3.6 %) 52 (48.6 %) 34 (6.8 %) 25 (73.5 %)
 Renal 59 (4.3 %) 31 (52.5 %) 675 (23.0 %) 129 (13.6 %) 33 (6.6 %) 18 (54.6 %)
 Gastroenterology 46 (3.4 %) 23 (50.0 %) 240 (8.2 %) 107 (44.6 %) 18 (3.6 %) 13 (72.2 %)
 Hematology/Immunology 105 (7.7 %) 57 (54.3 %) 313 (10.7 %) 144 (15.2 %) 34 (6.8 %) 21 (61.8 %)
 Metabolic disorder 132 (9.7 %) 61 (46.2 %) 769 (26.2 %) 210 (27.3 %) 75 (15.0 %) 38 (50.7 %)
 Malignancy 82 (6.0 %) 52 (63.4 %) 723 (24.6 %) 381 (52.7 %) 50 (10.0 %) 29 (58.0 %)
 Other 183 (13.5 %) 94 (51.4 %) 201 (6.8 %) 63 (31.3 %) 33 (6.6 %) 22 (66.7 %)
 None 258 (19.0 %) 127 (49.2 %) 648 (22.1 %) 142 (21.9 %) 144 (28.8 %) 84 (58.3 %)
Organ dysfunction
 1 241 (17.8 %) 122 (50.6 %) 683 (23.3 %) 82 (12.0 %) 45 (9.0 %) 27 (60.0 %)
 2 646 (47.6 %) 264 (40.9 %) 948 (32.3 %) 299 (31.5 %) 185 (37.0 %) 102 (55.1 %)
 3 309 (22.8 %) 163 (52.8 %) 725 (24.7 %) 302 (41.7 %) 153 (30.6 %) 89 (58.2 %)
 4 117 (8.6 %) 72 (61.5 %) 406 (13.8 %) 182 (44.8 %) 88 (17.6 %) 52 (59.1 %)
 5+ 45 (3.3 %) 28 (62.2 %) 175 (6.0 %) 83 (47.4 %) 29 (5.8 %) 20 (69.0 %)
  1. ECMO extracorporeal membrane oxygenation, RRT Renal replacement therapy