Fig. 2
From: Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries
Capillary red blood cell (RBC) supply rate, O2 saturation and capillary O2 supply rate profiles. Four representative 30-second profiles of capillary RBC supply rate (SR, blue circles), RBC hemoglobin O2 saturation (SO2, red squares) and O2 supply rate (qO2, green triangles) are shown in panels a–d. Based on 95 % confidence intervals (see Additional file 5: Table S1 in sham animals), SR was assessed as either slow, average or fast, while qO2 was assessed as being either low, average, or high. Capillaries were also categorized according to their functional capillary density, as either continuous (RBC SR >0 for 30 seconds, panels a,c), intermittent (if RBC supply rate came to arrest for at least one second, panel b, where oval marks interval of stopped-flow) or stopped (if RBCs remained at arrest, panel d, provided RBCs remained at arrest for 30 seconds). e,f qO2 distributions for sham and cecal ligation and perforation (CLP) animals, respectively. Legend for 30-second profile statistics (mean (coefficient of variation)). A significant difference between qO2 distributions was determined by Chi-squared analysis, p < 0.05