Biomarkers from distinct biological pathways improve early risk stratification in medical emergency patients: the multinational, prospective, observational TRIAGE study

Table 4 Reclassification statistics for ProADM and the three endpoints

	Mortality	ICU admission	High treatment priority
Models including clinical information readily available at ED admission
Net reclassification improvement (NRI)	0.11 (SE 0.03), p = 0.00004	0.06 (SE 0.02), p = 0.01345	0.02 (SE 0.01), p = 0.00572
Integrated discrimination improvement (IDI)	0.04 (SE 0.01), p = 0.0001	0.01 (SE 0.01), p = 0.0001	0.02 (SE 0.01), p = 0.0001
Models including full clinical information available at ED discharge
Net reclassification improvement (NRI)	0.09 (SE 0.02), p = 0.0003	0.08 (SE 0.02), p = 0.0001	0.02 (SE 0.01), p = 0.0072
Integrated discrimination improvement (IDI)	0.04 (SE 0.01), p = 0.0001	0.01 (SE 0.01), p = 0.00004	0.02 (SE 0.01), p = 0.0001
Models including information from initial triage scores
Net reclassification improvement (NRI)	0.23 (SE 0.03), p = 0.0001	0.10 (SE 0.02), p = 0.0001	0.06 (SE 0.01), p = 0.0001
Integrated discrimination improvement (IDI)	0.05 (SE 0.01), p = 0.0001	0.02 (SE 0.01), p = 0.0001	0.01 (SE 0.01), p = 0.0001

Initial clinical model includes age, gender, main presenting symptom and vital signs (i.e., heart rate, respiratory rate, blood pressure, temperature, consciousness); full clinical model includes age, gender, comorbidities, main presenting symptom, main diagnosis and vital signs; multimarker model includes ProADM, procalcitonin, copeptin; p value refers to comparison of combined model with the clinical model
ProADM pro-adrenomedullin, ICU intensive care unit, ED emergency department, SE standard error

ISSN: 1364-8535