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Table 4 Reclassification statistics for ProADM and the three endpoints

From: Biomarkers from distinct biological pathways improve early risk stratification in medical emergency patients: the multinational, prospective, observational TRIAGE study

  Mortality ICU admission High treatment priority
Models including clinical information readily available at ED admission   
 Net reclassification improvement (NRI) 0.11 (SE 0.03), p = 0.00004 0.06 (SE 0.02), p = 0.01345 0.02 (SE 0.01), p = 0.00572
 Integrated discrimination improvement (IDI) 0.04 (SE 0.01), p = 0.0001 0.01 (SE 0.01), p = 0.0001 0.02 (SE 0.01), p = 0.0001
Models including full clinical information available at ED discharge   
 Net reclassification improvement (NRI) 0.09 (SE 0.02), p = 0.0003 0.08 (SE 0.02), p = 0.0001 0.02 (SE 0.01), p = 0.0072
 Integrated discrimination improvement (IDI) 0.04 (SE 0.01), p = 0.0001 0.01 (SE 0.01), p = 0.00004 0.02 (SE 0.01), p = 0.0001
Models including information from initial triage scores   
 Net reclassification improvement (NRI) 0.23 (SE 0.03), p = 0.0001 0.10 (SE 0.02), p = 0.0001 0.06 (SE 0.01), p = 0.0001
 Integrated discrimination improvement (IDI) 0.05 (SE 0.01), p = 0.0001 0.02 (SE 0.01), p = 0.0001 0.01 (SE 0.01), p = 0.0001
  1. Initial clinical model includes age, gender, main presenting symptom and vital signs (i.e., heart rate, respiratory rate, blood pressure, temperature, consciousness); full clinical model includes age, gender, comorbidities, main presenting symptom, main diagnosis and vital signs; multimarker model includes ProADM, procalcitonin, copeptin; p value refers to comparison of combined model with the clinical model
  2. ProADM pro-adrenomedullin, ICU intensive care unit, ED emergency department, SE standard error