Age, yr, median [25th–75th percentile]
|
59.3 [43–70]
|
64.5 [53.25–72]
|
Males, n (%)
|
38 (73.1)
|
32 (66.7)
|
Comorbidities, n (%)
|
Chronic respiratory failure
|
7 (13.5)
|
4 (8.3)
|
Chronic kidney failure
|
2 (3.8)
|
3 (6.2)
|
Chronic heart failure
|
4 (7.7)
|
2 (4.2)
|
Cause of immunosuppression, n (%)
|
Solid malignancy
|
15 (28.8)
|
8 (16.7)
|
Hematological malignancy
|
31 (59.6)
|
30 (62.5)
|
HIV infection
|
3 (5.8)
|
5 (10.4)
|
Steroid treatment
|
13 (25.0)
|
15 (31.2)
|
Other immunosuppressant drugs
|
23 (44.2)
|
14 (29.2)
|
Final etiology of ARF,b n (%)
|
Sepsis
|
25 (48.1)
|
25 (52.0)
|
Cardiogenic pulmonary edema
|
5 (9.6)
|
2 (4.1)
|
Noninfectious pulmonary disease
|
5 (6.8)
|
7 (14.5)
|
Lung involvement by the underlying disease
|
7 (13.4)
|
9 (18.7)
|
Large pleural effusion
|
0 (0)
|
1 (2.0)
|
Pneumocystis pneumonia
|
5 (9.6)
|
2 (4.1)
|
Miscellaneousc
|
3 (5.7)
|
1 (2.0)
|
No diagnosis
|
2 (3.8 %)
|
1 (2.0)
|
SAPS II at ICU admission, median [25th–75th percentile]
|
42 [29.5–52]
|
37.5 [31.5–46.5]
|
SOFA score at randomization, median [25th–75th percentile]
|
3.5 [2–6]
|
3 [2–5]
|
Days since respiratory symptom onset
|
3 [2–8]
|
3 [2–7.25]
|
Clinical status at randomization
|
Respiratory rate, breaths/min, median [25th-75th percentile]
|
26 [21.7–31.2]
|
27 [22–32.2]
|
SpO2, %, median [25th-75th percentile]
|
96 [94–98]
|
96 [95–98.2]
|
Estimated PaO2/FiO2 ratio at admission
|
128 [48–178]
|
100 [40–156]
|
Mean arterial pressure, mmHg, median [25th-75th percentile]
|
86.8 [82.2–95.3]
|
80 [74–89.3]
|
Normal Glasgow Coma Scale score, n (%)
|
49 (94.2)
|
48 (100)
|
Confusion, n (%)
|
4 (7.7)
|
1 (2.1)
|