Skip to main content
Fig. 3 | Critical Care

Fig. 3

From: Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis

Fig. 3

MFG-E8-derived short peptide 68 (MSP68) attenuates lung damage after cecal ligation and puncture (CLP). Male C57BL/6 mice were sham-operated or subjected to CLP with injection of vehicle (normal saline) or MSP68 (1 mg/kg body weight) at 2 h after CLP. The lung tissues were harvested at 20 h after CLP. a Sections of lung tissues were stained with hematoxylin and eosin, and examined under light microscopy. Representative images at original magnification × 200 are shown. b Histological lung injury scores from the above mentioned mice groups, determined as described in “Methods”, are shown. c Protein was extracted from the lung tissues to measure interleukin-6 (IL-6) levels by enzyme-linked immunosorbent assay. Data are expressed as means ± standard error of the mean (n = 4–6/group) and compared by one-way analysis of variance and Student–Newman–Keuls test; *P <0.05 versus sham and # P <0.05 versus vehicle

Back to article page