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Fig. 2 | Critical Care

Fig. 2

From: Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis

Fig. 2

MFG-E8-derived short peptide 68 (MSP68) reduces organ injury after cecal ligation and puncture (CLP). Male C57BL/6 mice were sham-operated or subjected to CLP with injection of vehicle (normal saline) or MSP68 (1 mg/kg body weight) at 2 h after CLP. Blood samples were collected at 20 h after CLP to measure aspartate aminotransferase (AST) using the commercial assay kit (a), interleukin-6 (IL-6) (b) and tumor necrosis factor-α (TNF-α) (c) using enzyme-linked immunosorbent assay. Data are expressed as means ± standard error of the mean (n = 6 mice/group) and compared by one-way analysis of variance and Student–Newman–Keuls method; *P <0.05 versus sham and # P <0.05 versus vehicle

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Critical Care

ISSN: 1364-8535