Table 2 Mediators and infections of the study population
Control | SIRS | Sepsis | Severe sepsis | Septic shock | p value | |
|---|---|---|---|---|---|---|
Number of subjects | 55 | 107 | 176 | 84 | 73 | |
Mediator levels | ||||||
PCT (ng/ml) | 0.11 (0.09–0.13) | 0.64 (0.56–0.71) | 1.20 (1.09–6.67) | 7.97 (3.06–12.3) | 13.2 (1.21–33.0) | <0.0001 |
Ang-1 (ng/ml) | 9.54 (7.56–10.89) | 9.11 (5.67–11.2) | 7.57 (6.78–8.75) | 5.32 (4.56–6.24) | 3.06 (0.99–7.45) | <0.0001 |
Ang-2 (ng/ml) | 3.41 (1.45–6.23) | 5.42 (5.18–5.91) | 13.0 (12.0–6.24) | 18.7 (12.1–19.4) | 15.7 (11.4–27.8) | <0.0001 |
Tie-2 (ng/ml) | 107.9 (92.1–129.3) | 113.0 (99.8–189.9) | 174.7 (134.2–220.4) | 272.1 (176.5–358.4) | 311.9 (149.9–415.2) | <0.0001 |
Ang-2/Ang-1 ratio | 0.49 (0.16–0.61) | 0.73 (0.51–0.91) | 1.73 (1.37–2.00) | 3.42 (1.93–4.15) | 5.14 (1.50–18.95) | <0.0001 |
Ang-1/Tie-2 ratio (×103) | 82.4 (68.3–98.0) | 63.0 (40.6–84.4) | 43.1 (34.9–62.2) | 17.0 (11.5–28.8) | 8.7 (1.8–41) | <0.0001 |
Infection data (n) | ||||||
Respiratory (lung) | AECOPD (77) | Pneumonia (121) | Pneumonia (60) | Pneumonia (50) | 0.564 | |
Asthma (9) | ||||||
PE (2) | ||||||
Intra-abdominal sites | Pancreatitis (7) | IAI (24) | IAI (14) | IAI (15) | 0.558 | |
Cerebral | Stroke (8) | Meningitis (15) | Meningitis (5) | Meningitis (6) | 0.695 | |
Urinary | Pyelonephritis (10) | Pyelonephritis (5) | Pyelonephritis (2) | 0.754 | ||
Other | DKA (4) | Skin/soft tissue infection (6) | ||||
28-day mortality, n (%) | 0 | 15 (14.0) | 32 (18.2) | 36 (42.9) | 45 (61.6) | <0.0001 |
Missing data, n (%) | 0 | 13 (10.8) | 18 (9.3) | 9 (9.7) | 8 (9.9) | 0.770 |