From: Procalcitonin and mortality in status epilepticus: an observational cohort study
Survivors (n = 70) | Non-survivors (n = 21) | P value | |||
---|---|---|---|---|---|
Demographics | |||||
Male, n (%) | 32 | (45.7) | 11 | (52.4) | 0.591 |
Age, years, median (IQR) | 60.6 | (48.1 − 73.9) | 65.3 | (58.8 − 74.3) | 0.451 |
Clinical features known at status epilepticus onset | |||||
ᅟStatus epilepticus etiology grouped according to the ILAE1, n (%) | 0.241* | ||||
ᅟAcute symptomatic seizures | 37 | (52.9) | 14 | (66.7) | |
ᅟRemote symptomatic unprovoked seizures | 8 | (11.4) | 4 | (19.1) | |
ᅟSymptomatic seizures due to progressive central nervous system disorders | 5 | (7.1) | 1 | (4.8) | |
ᅟUnprovoked seizures of unknown etiology | 20 | (28.6 | 2 | (9.5) | |
ᅟInfectious etiologies of status epilepticus | 5 | (7.1) | 1 | (4.8) | |
ᅟSTESS2 at status epilepticus onset, median (IQR) | 3 | (2 − 4) | 4 | (4 − 6) | <0.001 |
ᅟSTESS2 characteristics | |||||
ᅟᅟStuporous/comatose, n (%) | 38 | (54.3) | 16 | (76.2) | |
ᅟᅟWorst seizure type, n (%) | |||||
ᅟᅟᅟSimple partial/complex/absence | 36 | (51.4) | 5 | (23.8) | |
ᅟᅟᅟGeneralized convulsive | 13 | (18.6) | 1 | (4.8) | |
ᅟᅟᅟNonconvulsive status epilepticus in coma | 21 | (30.0) | 15 | (71.4) | |
ᅟᅟAge ≥65 years, n (%) | 31 | (44.3) | 12 | (57.1) | |
ᅟᅟNo history of seizures, n (%) | 43 | (61.4) | 16 | (76.2) | |
ᅟCharlson comorbidity index, median (IQR) | 2 | (1 − 3) | 4 | (3 − 6) | <0.001 |
Laboratory findings | |||||
ᅟProcalcitonin serum level at status epilepticus onset, μg/L, median (IQR) | 0.18 | (0.08 − 0.41) | 0.58 | (0.12 − 1.27) | 0.009 |
ᅟC-reactive protein serum level at status epilepticus onset, mg/L, median (IQR) | 18.9 | (3.7 − 47.7) | 26.6 | (17.1 − 54.7) | 0.151 |
ᅟAlbumin serum level at status epilepticus onset, g/L, median (IQR) | 29 | (24 − 34) | 27 | (20 − 30) | 0.050 |
Course of status epilepticus | |||||
ᅟStatus epilepticus duration, days, median (IQR) | 1 | (0.5 − 2) | 2 | (1 − 4) | |
ᅟComplications during status epilepticus | |||||
ᅟᅟInfections, n (%) | 18 | (25.7) | 10 | (47.6) | 0.065* |
ᅟᅟRespiratory tract infections, n (%) | 16 | (22.9) | 8 | (38.1) | |
ᅟᅟBlood stream infections, n (%) | 4 | (5.7) | 2 | (9.5) | |
ᅟᅟUrinary tract infections, n (%) | 2 | (2.8) | 3 | (14.3) | |
ᅟᅟHemodynamic instability requiring vasopressors, n (%) | 5 | (7.1) | 4 | (19.1) | |
Treatment during status epilepticus | |||||
ᅟAntiepileptic drugs, median (IQR) | 3 | (2 − 4) | 4 | (3 − 5) | 0.423 |
ᅟUse of anesthetic drugs, n (%) | 34 | (48.6) | 15 | (71.4) | 0.083* |
ᅟMechanical ventilation, n (%) | 41 | (58.6) | 18 | (85.7) | 0.035* |