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Table 3 London Dataset patient characteristics and univariate analysis

From: Validation and analysis of prognostic scoring systems for critically ill patients with cirrhosis admitted to ICU

Variable All patients (n = 115) ICU survivor (n = 72) ICU death (n = 43) P value
Age, mean (range) 50.9 (22.0–82.0) 50.0 (28.0–71.0) 52.44 (22.0–82.0) 0.30
Gender, male, n (%) 78 (67.8 %) 51 (70.8 %) 27 (62.8 %) 0.49
Ascites, any, n (%) 47 (40.9 %) 23 (31.9 %) 24 (55.8 %) 0.023
Sodium, mmol/L, median (IQR) 137.0 (133.0–142.0) 138.0 (133.8–142.0) 137.0 (130.5–140.5) 0.34
Potassium, mmol/L, mean (range) 4.2 (1.9–6.8) 4.1 (1.9–6.8) 4.3 (1.9–6.4) 0.17
Urea, μmol/L, median (IQR) 7.5 (4.3–14.5) 6.7 (4.2–11.6) 10.3 (4.7–15.2) 0.086
Lactate, mmol/L, median (IQR) 2.4 (1.5–4.8) 1.9 (1.3–3.1) 3.9 (2.2–6.8) <0.001
Creatine, μmol/L, median (IQR) 86.0 (56.0–164.5) 67.5 (52.0–135.2) 112.0 (75.5–180.0) 0.051
WCC, × 109/L, mean (range) 12.5 (0.7–35.5) 12.7 (1.8–35.5) 12.1 (0.7–31.4) 0.68
Bilirubin, μmol/L, median (IQR) 40.0 (16.0–102.0) 28.0 (15.0–82.3) 60.0 (23.0–197.5) 0.027
PT ratio, median (IQR) 1.5 (1.2–2.0) 1.4 (1.2–1.7) 1.9 (1.5–2.2) <0.001
Albumin, g/L median (IQR) 22.0 (18.0–27.5) 19.0 (16.5–27.5) 21.0 (17.0–27.0) 0.16
Platelets, × 109/L, median (IQR) 120.0 (67.0–215.0) 122.0 (80.0–235.0) 116.0 (46.5–174.0) 0.11
PaO2, kPa, median (IQR) 12.1 (9.8–17.5) 12.9 (10.1–19.1) 11.1 (9.7–13.4) 0.11
PaO2/FiO2 ratio, mean (range) 30.2 (6.0–77.0) 34.0 (7.0–77.0) 23.9 (6.0–59.0) 0.0011
Arterial pH, median (IQR) 7.32 (7.25–7.41) 7.34 (7.26–7.40) 7.31 (7.21–7.42) 0.34
Bicarbonate, mmol/L, mean (range) 20.9 (7.3–35.2) 21.3 (7.7–31.1) 20.2 (7.3–35.2) 0.33
MCV, fL, mean (range) 97.2 (80.0–124.0) 96.4 (80.0–124.0) 98.5 (82.9–119.0) 0.25
Haemocrit, median (IQR) 0.29 (0.24–0.34) 0.29 (0.24–0.34) 0.29 (0.24–0.33) 0.80
APACHE II, mean (range) 16.9 (5.0–29.0) 15.4 (5.0–27.0) 19.4 (9.0–29.0) <0.001
SOFA, mean (range) 6.4 (0.0–14.0 ) 5.4 (0.0–13.0) 8.0 (2.0–14.0) <0.001
MELD, median (IQR) 18.0 (12.0–24.0) 14.0 (9.8–20.0) 23.0 (17.5–26.0) <0.001
UKELD, median (IQR) 51.0 (46.0–56.0) 48.0 (44.8–55.3) 54.0 (50.0–59.5) <0.001
CTP, median (IQR) 10.0 (8.0–11.0) 9.0 (8.0–11.0) 11.0 (9.5–11.0) <0.001
CTP + L, median (IQR) 13.0 (10.0–16.0) 11.5 (9.0–14.0) 15.0 (13.0–18.0) <0.001
CLIF-SOFA, median (IQR) 10.0 (7.0–12.0) 9.0 (7.0–12.0) 12.0 (11.0–14.0) <0.001
RFH, median (IQR) −0.50 (−3.27–1.34) −1.60 (−3.78–0.00) 1.29 (−0.27–2.65) <0.001
  1. WCC white cell count, PT prothrombin time, PaO2, arterial partial pressure of oxygen, FiO2, inspired oxygen fraction, MCV mean corpuscular volume, APACHE II acute physiology and chronic health evaluation II, SOFA sequential organ failure assessment, MELD model of end-stage liver disease, UKELD United Kingdom model for end-stage liver disease, CTP Child-Turcotte Pugh, CTP + L Child-Turcotte Pugh + lactate, CLIF-SOFA chronic liver failure sequential organ failure assessment, RFH Royal Free Hospital score
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Critical Care

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