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Table 3 London Dataset patient characteristics and univariate analysis

From: Validation and analysis of prognostic scoring systems for critically ill patients with cirrhosis admitted to ICU

Variable

All patients (n = 115)

ICU survivor (n = 72)

ICU death (n = 43)

P value

Age, mean (range)

50.9 (22.0–82.0)

50.0 (28.0–71.0)

52.44 (22.0–82.0)

0.30

Gender, male, n (%)

78 (67.8 %)

51 (70.8 %)

27 (62.8 %)

0.49

Ascites, any, n (%)

47 (40.9 %)

23 (31.9 %)

24 (55.8 %)

0.023

Sodium, mmol/L, median (IQR)

137.0 (133.0–142.0)

138.0 (133.8–142.0)

137.0 (130.5–140.5)

0.34

Potassium, mmol/L, mean (range)

4.2 (1.9–6.8)

4.1 (1.9–6.8)

4.3 (1.9–6.4)

0.17

Urea, μmol/L, median (IQR)

7.5 (4.3–14.5)

6.7 (4.2–11.6)

10.3 (4.7–15.2)

0.086

Lactate, mmol/L, median (IQR)

2.4 (1.5–4.8)

1.9 (1.3–3.1)

3.9 (2.2–6.8)

<0.001

Creatine, μmol/L, median (IQR)

86.0 (56.0–164.5)

67.5 (52.0–135.2)

112.0 (75.5–180.0)

0.051

WCC, × 109/L, mean (range)

12.5 (0.7–35.5)

12.7 (1.8–35.5)

12.1 (0.7–31.4)

0.68

Bilirubin, μmol/L, median (IQR)

40.0 (16.0–102.0)

28.0 (15.0–82.3)

60.0 (23.0–197.5)

0.027

PT ratio, median (IQR)

1.5 (1.2–2.0)

1.4 (1.2–1.7)

1.9 (1.5–2.2)

<0.001

Albumin, g/L median (IQR)

22.0 (18.0–27.5)

19.0 (16.5–27.5)

21.0 (17.0–27.0)

0.16

Platelets, × 109/L, median (IQR)

120.0 (67.0–215.0)

122.0 (80.0–235.0)

116.0 (46.5–174.0)

0.11

PaO2, kPa, median (IQR)

12.1 (9.8–17.5)

12.9 (10.1–19.1)

11.1 (9.7–13.4)

0.11

PaO2/FiO2 ratio, mean (range)

30.2 (6.0–77.0)

34.0 (7.0–77.0)

23.9 (6.0–59.0)

0.0011

Arterial pH, median (IQR)

7.32 (7.25–7.41)

7.34 (7.26–7.40)

7.31 (7.21–7.42)

0.34

Bicarbonate, mmol/L, mean (range)

20.9 (7.3–35.2)

21.3 (7.7–31.1)

20.2 (7.3–35.2)

0.33

MCV, fL, mean (range)

97.2 (80.0–124.0)

96.4 (80.0–124.0)

98.5 (82.9–119.0)

0.25

Haemocrit, median (IQR)

0.29 (0.24–0.34)

0.29 (0.24–0.34)

0.29 (0.24–0.33)

0.80

APACHE II, mean (range)

16.9 (5.0–29.0)

15.4 (5.0–27.0)

19.4 (9.0–29.0)

<0.001

SOFA, mean (range)

6.4 (0.0–14.0 )

5.4 (0.0–13.0)

8.0 (2.0–14.0)

<0.001

MELD, median (IQR)

18.0 (12.0–24.0)

14.0 (9.8–20.0)

23.0 (17.5–26.0)

<0.001

UKELD, median (IQR)

51.0 (46.0–56.0)

48.0 (44.8–55.3)

54.0 (50.0–59.5)

<0.001

CTP, median (IQR)

10.0 (8.0–11.0)

9.0 (8.0–11.0)

11.0 (9.5–11.0)

<0.001

CTP + L, median (IQR)

13.0 (10.0–16.0)

11.5 (9.0–14.0)

15.0 (13.0–18.0)

<0.001

CLIF-SOFA, median (IQR)

10.0 (7.0–12.0)

9.0 (7.0–12.0)

12.0 (11.0–14.0)

<0.001

RFH, median (IQR)

−0.50 (−3.27–1.34)

−1.60 (−3.78–0.00)

1.29 (−0.27–2.65)

<0.001

  1. WCC white cell count, PT prothrombin time, PaO2, arterial partial pressure of oxygen, FiO2, inspired oxygen fraction, MCV mean corpuscular volume, APACHE II acute physiology and chronic health evaluation II, SOFA sequential organ failure assessment, MELD model of end-stage liver disease, UKELD United Kingdom model for end-stage liver disease, CTP Child-Turcotte Pugh, CTP + L Child-Turcotte Pugh + lactate, CLIF-SOFA chronic liver failure sequential organ failure assessment, RFH Royal Free Hospital score