Parameter | Baseline measurements (t0) | Measurements 3Â hours after LPS infusion (t1) | Measurements after late resuscitation (t2) |
---|---|---|---|
Control group (n = 8) |  | ||
 Cardiac output (ml/minute) | 137 ± 21 | 115 ± 32 |  |
 Mean arterial pressure (mmHg) | 78 ± 4 | 66 ± 3* |  |
 Heart rate (bpm) | 235 ± 12 | 244 ± 12 |  |
 pH | 7.33 ± 0.01 | 7.28 ± 0.04 |  |
 pCO2 (mmHg) | 39 ± 1.8 | 36 ± 2.0 |  |
 pO2 (mmHg) | 201 ± 3.99 | 201 ± 6.64 |  |
 | Baseline measurements (t0) | Post-LPS measurements (t1) |  |
LPS resuscitation group (n = 10) |  | ||
 Cardiac output (ml/minute) | 118 ± 28 | 111 ± 36 |  |
 Mean arterial pressure (mmHg) | 82 ± 3 | 80 ± 8 |  |
 Heart rate (bpm) | 240 ± 7 | 292 ± 14*†|  |
 pH | 7.34 ± 0.01 | 7.16 ± 0.02*†|  |
 pCO2 (mmHg) | 36 ± 2 | 38.5 ± 2 |  |
 pO2 (mmHg) | 196 ± 5 | 209 ± 3* |  |
 Lactate (mmol/l) | 1.10 ± 0.07 | 3.87 ± 0.32*†|  |
 | Baseline measurements (t0) | Post-LPS measurements (t1) | Late resuscitation measurements (t2) |
LPS non-resuscitation group (n = 10) | |||
 Cardiac output (ml/minute) | 135 ± 17 | 50 ± 19* | 343 ± 80*†|
 Mean arterial pressure (mmHg) | 76 ± 9 | 57 ± 4 | 53 ± 4 |
 Heart rate (bpm) | 247 ± 10 | 268 ± 29 | 294 ± 14 |
 pH | 7.35 ± 0.01 | 7.14 ± 0.01*†| 7.12 ± 0.01*†|
 pCO2 (mmHg) | 35 ± 2 | 37 ± 2 | 34 ± 3 |
 pO2 (mmHg) | 192 ± 3 | 189 ± 7 | 193 ± 8 |
 Lactate (mmol/l) | 1.38 ± 0.10 | 4.30 ± 0.33*†| 5.00 ± 0.77*†|