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Table 4 Clinical outcomes by definition of severe sepsis

From: Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Outcome Physician diagnosis Both criteria Consensus criteria p value*
Vasoactive-free days, median (IQR) 27 (22–28) 22 (6–26) 26 (17–28) <0.001
Ventilator-free days, median (IQR) 19 (2–27) 16 (0–24) 18 (0–26) 0.07
NPMODSa 47 (34) 131 (44) 97 (36) 0.10
PICU mortality 23 (17) 82 (27) 57 (21) 0.042
At least mild disabilityb 24 (22) 67 (31) 50 (24) 0.15
At least moderate disabilityc 14 (13) 36 (17) 37 (18) 0.46
  1. Data presented as n (%) unless otherwise noted
  2. IQR interquartile range, NPMODS new or progressive multiorgan dysfunction syndrome, PICU pediatric intensive care unit
  3. *Statistical comparisons using Kruskal-Wallis or Fisher’s exact test
  4. aNPMODS considered starting the day after sepsis recognition
  5. bAny increase in Pediatric Overall Performance Category from baseline to hospital discharge in the 534 hospital survivors
  6. cDischarge Pediatric Overall Performance Category ≥3 and an increase of at least 1 from baseline in the 534 hospital survivors