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Table 3 Therapies used within the 48-h data collection window by definition of severe sepsis

From: Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Therapy Physician diagnosis Both criteria Consensus criteria p value*
Vasoactive infusionsa 53 (39) 209 (69) 105 (39) <0.001
Invasive mechanical ventilation 92 (67) 229 (76) 192 (72) 0.14
Corticosteroids 46 (36) 132 (44) 110 (41) 0.13
Albumin 24 (18) 90 (30) 45 (17) <0.001
Blood productsb 39 (28) 159 (53) 73 (27) <0.001
Insulinc 4 (3) 32 (11) 25 (9) 0.02
G/GM-CSF 2 (1) 17 (6) 6 (2) 0.04
IVIG 7 (5) 28 (9) 10 (4) 0.02
RRTd 13 (9) 57 (19) 24 (9) 0.001
Plasma exchange 1 (1) 3 (1) 2 (1) 0.94
ECMO 3 (2) 14 (5) 16 (6) 0.23
  1. Data presented as n (%)
  2. G/GM-CSF granulocyte/granulocyte-monocyte colony stimulating factor, IVIG intravenous immunoglobulin, RRT renal replacement therapy, ECMO extracorporeal membrane oxygenation
  3. *Statistical comparisons using Fisher’s exact test
  4. aIncludes dopamine >5 μg/kg/min, dobutamine >5 μg/kg/min, or any dose of epinephrine, norepinephrine, vasopressin, phenylephrine, milrinone, levosimendan, or vasodilator
  5. bIncludes packed red blood cells, platelets, fresh frozen plasma, cryoprecipitate, granulocytes, and whole blood
  6. cIncludes intravenous insulin by continuous infusion only
  7. dIncludes hemodialysis, all continuous renal replacement modalities, and peritoneal dialysis