Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Table 3 Therapies used within the 48-h data collection window by definition of severe sepsis

Therapy	Physician diagnosis	Both criteria	Consensus criteria	p value*
Vasoactive infusions^a	53 (39)	209 (69)	105 (39)	<0.001
Invasive mechanical ventilation	92 (67)	229 (76)	192 (72)	0.14
Corticosteroids	46 (36)	132 (44)	110 (41)	0.13
Albumin	24 (18)	90 (30)	45 (17)	<0.001
Blood products^b	39 (28)	159 (53)	73 (27)	<0.001
Insulin^c	4 (3)	32 (11)	25 (9)	0.02
G/GM-CSF	2 (1)	17 (6)	6 (2)	0.04
IVIG	7 (5)	28 (9)	10 (4)	0.02
RRT^d	13 (9)	57 (19)	24 (9)	0.001
Plasma exchange	1 (1)	3 (1)	2 (1)	0.94
ECMO	3 (2)	14 (5)	16 (6)	0.23

Data presented as n (%)
G/GM-CSF granulocyte/granulocyte-monocyte colony stimulating factor, IVIG intravenous immunoglobulin, RRT renal replacement therapy, ECMO extracorporeal membrane oxygenation
*Statistical comparisons using Fisher’s exact test
^aIncludes dopamine >5 μg/kg/min, dobutamine >5 μg/kg/min, or any dose of epinephrine, norepinephrine, vasopressin, phenylephrine, milrinone, levosimendan, or vasodilator
^bIncludes packed red blood cells, platelets, fresh frozen plasma, cryoprecipitate, granulocytes, and whole blood
^cIncludes intravenous insulin by continuous infusion only
^dIncludes hemodialysis, all continuous renal replacement modalities, and peritoneal dialysis

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