Skip to main content

Table 2 Laboratory values within the 48-h data collection window by definition of severe sepsis

From: Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Laboratory examination

Physician diagnosis

Both criteria

Consensus criteria

p value*

Percenta

Median (IQR)

Percenta

Median (IQR)

Percenta

Median (IQR)

WBC, max (103/μl)

92 %

10.1 (7.3–16.6)

97 %

14.9 (7.5–22.7)

91 %

14.6 (8.8–20.8)

<0.001

Platelets, min (103/μl)

91 %

148 (70–262)

96 %

95 (39–195)

89 %

157 (77–287)

<0.001

BUN, max (mg/dl)

83 %

13 (8–22)

93 %

21 (12–41)

92 %

18 (10–31)

<0.001

Creatinine, max (mg/dl)

92 %

0.4 (0.3–0.6)

97 %

0.5 (0.3–0.9)

97 %

0.4 (0.3–0.7)

<0.001

ALT, max (IU/L)

55 %

39 (25–67)

77 %

53 (28–123)

62 %

50 (26–110)

0.09

Total bilirubin, max (mg/dl)

53 %

0.7 (0.4–1.7)

73 %

1.0 (0.5–2.9)

59 %

0.7 (0.4–3.0)

0.02

Albumin, min (g/dl)

66 %

2.6 (2.2–3.0)

81 %

2.5 (2.2–3.0)

71 %

2.8 (2.3–3.3)

<0.001

INR, max

37 %

1.3 (1.2–1.7)

64 %

1.3 (1.2–1.8)

42 %

1.3 (1.1–1.8)

0.80

Lactate, max (mmol/L)

62 %

1.4 (1.1–2.0)

75 %

2.0 (1.2–3.8)

62 %

1.6 (1.1–2.8)

0.001

ScvO2, min (%)

28 %

70 (57–75)

46 %

65 (52–74)

30 %

65 (49–73)

0.50

PaO2/FiO2 ratio, min (mmHg)

47 %

138 (89–233)

72 %

160 (100–236)

51 %

144 (87–275)

0.79

C-reactive peptide, max (mg/dl)

39 %

7.1 (2.1–17.8)

64 %

9.3 (2.8–20.8)

43 %

3.8 (1.6–9.7)

<0.001

Procalcitonin, max (ng/ml)

12 %

3.5 (1.1–11.6)

22 %

6.4 (1.4–23.0)

6 %

1.3 (0.24–5.4)

0.01

  1. max maximum value within the 48-h window around the study day (9:00 am before to 9:00 am after the study day), min minimum value within the 48-h window around the study day (9:00 am before to 9:00 am after the study day), PaO2/FiO2 ratio of partial pressure of oxygen to fraction of inspired oxygen, WBC white blood cell count, BUN blood urea nitrogen, ALT alanine aminotransferase, INR international normalized ratio, ScvO2 central venous oxygen saturation
  2. *Statistical comparisons using Kruskal-Wallis test
  3. aProportion of each group with available laboratory results