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Table 2 Laboratory values within the 48-h data collection window by definition of severe sepsis

From: Discordant identification of pediatric severe sepsis by research and clinical definitions in the SPROUT international point prevalence study

Laboratory examination Physician diagnosis Both criteria Consensus criteria p value*
Percenta Median (IQR) Percenta Median (IQR) Percenta Median (IQR)
WBC, max (103/μl) 92 % 10.1 (7.3–16.6) 97 % 14.9 (7.5–22.7) 91 % 14.6 (8.8–20.8) <0.001
Platelets, min (103/μl) 91 % 148 (70–262) 96 % 95 (39–195) 89 % 157 (77–287) <0.001
BUN, max (mg/dl) 83 % 13 (8–22) 93 % 21 (12–41) 92 % 18 (10–31) <0.001
Creatinine, max (mg/dl) 92 % 0.4 (0.3–0.6) 97 % 0.5 (0.3–0.9) 97 % 0.4 (0.3–0.7) <0.001
ALT, max (IU/L) 55 % 39 (25–67) 77 % 53 (28–123) 62 % 50 (26–110) 0.09
Total bilirubin, max (mg/dl) 53 % 0.7 (0.4–1.7) 73 % 1.0 (0.5–2.9) 59 % 0.7 (0.4–3.0) 0.02
Albumin, min (g/dl) 66 % 2.6 (2.2–3.0) 81 % 2.5 (2.2–3.0) 71 % 2.8 (2.3–3.3) <0.001
INR, max 37 % 1.3 (1.2–1.7) 64 % 1.3 (1.2–1.8) 42 % 1.3 (1.1–1.8) 0.80
Lactate, max (mmol/L) 62 % 1.4 (1.1–2.0) 75 % 2.0 (1.2–3.8) 62 % 1.6 (1.1–2.8) 0.001
ScvO2, min (%) 28 % 70 (57–75) 46 % 65 (52–74) 30 % 65 (49–73) 0.50
PaO2/FiO2 ratio, min (mmHg) 47 % 138 (89–233) 72 % 160 (100–236) 51 % 144 (87–275) 0.79
C-reactive peptide, max (mg/dl) 39 % 7.1 (2.1–17.8) 64 % 9.3 (2.8–20.8) 43 % 3.8 (1.6–9.7) <0.001
Procalcitonin, max (ng/ml) 12 % 3.5 (1.1–11.6) 22 % 6.4 (1.4–23.0) 6 % 1.3 (0.24–5.4) 0.01
  1. max maximum value within the 48-h window around the study day (9:00 am before to 9:00 am after the study day), min minimum value within the 48-h window around the study day (9:00 am before to 9:00 am after the study day), PaO2/FiO2 ratio of partial pressure of oxygen to fraction of inspired oxygen, WBC white blood cell count, BUN blood urea nitrogen, ALT alanine aminotransferase, INR international normalized ratio, ScvO2 central venous oxygen saturation
  2. *Statistical comparisons using Kruskal-Wallis test
  3. aProportion of each group with available laboratory results