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Table 7 Univariate and multivariate analyses to assess variables associated with changes in ICU mortality

From: Improvement of antibiotic therapy and ICU survival in severe non-pneumococcal community-acquired pneumonia: a matched case–control study

Variable

Survival

No survival

Univariate analysis

Multivariate analysis:

(n = 107)

(n = 37)

p value

OR (95 % CI); p value

Age over 65 years

46 (43.0)

18 (48.6)

0.57

 

Overweight

27 (25.2)

8 (21.6)

0.83

 

Alcohol use

23 (21.5)

15 (40.5)

0.03

 

Active smoker

36 (33.6)

16 (43.2)

0.33

 

Diabetes mellitus

24 (22.4)

9 (24.3)

0.83

 

Cardiomyopathy

28 (26.2)

13 (35.1)

0.30

 

COPD

49 (45.8)

19 (51.4)

0.57

 

Immunosuppression

13 (12.1)

5 (13.5)

0.78

 

Shock at ICU admission

56 (52.3)

30 (81.1)

<0.01

3.96 (1.29–12.14); 0.02

Invasive mechanical ventilation

73 (68.2)

33 (89.2)

0.02

 

Acute kidney injury

36 (33.6)

24 (64.9)

<0.01

4.56 (1.60–13.02); <0.01

Rapid radiographic spread

56 (52.3)

21 (56.8)

0.70

 

Bacteremia

27 (25.2)

11 (29.7)

0.67

 

Combined therapy

96 (89.7)

24 (64.9)

<0.01

0.23 (0.07–0.74); 0.01

AB initiated within 3 hours

67 (62.6)

6 (16.2)

<0.01

0.07 (0.02–0.22); <0.01

Combined BL and M therapy

52 (48.6)

15 (40.5)

0.45

 

Combined BL and FQ therapy

33 (30.8)

6 (16.2)

0.09

 
  1. Data are presented as n (%). Significant p values are indicated in bold. AB antibiotic, BL beta-lactam, CI confidence interval, COPD chronic obstructive pulmonary disease, FQ fluoroquinolone, ICU intensive care unit, M macrolide, OR odds ratio