Fig. 4

Inhaled nitric oxide (iNO) impacts the outcome after cardiac arrest. Comparison of animals treated with 20 ppm iNO (n = 10) or Control (n = 10). Mean ± standard error of the mean: *p ≤0.05, comparing iNO to Control. ROSC return of spontaneous circulation, BL baseline (i.e., 5 minutes prior to cardiac arrest), AU arbitrary units. a Number of animals that achieved ROSC or were alive on days 1 (+1), 2 (+2), 3 (+3), 4 (+4) or 5 (+5) post cardiopulmonary resuscitation (CPR). b Overall performance categories (OPC): OPC 1, normal, no obvious neurologic damage; OPC 2, moderate disability, animals being conscious and aware, standing but unable to walk; OPC 3, severe disability; animals being neither fully aware nor unconscious, but with reaction to pain and auditory stimuli, not able to stand or walk; OPC 4, coma; OPC 5, death or brain death. c S-100 protein levels measured at BL, 10 minutes (1/6), 30 minutes (1/2), or 6 hours after ROSC. S-100 serum levels were employed as an indicator of the degree of cerebral ischemia-reperfusion injury. d Results from the blinded neurohistopathological evaluation in animals euthanized 24 hours after ROSC due to their inability to rise